Antitumor antibiotic BMY-42448

Abstract

An antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.

We claim: 
     
       1. A process for producing the antibiotic BMY-42448 having the formula ##STR2## which comprises cultivating a BMY-42448-producing strain of Micromonospora narashinoensis, said strain having the identifying characteristics of Strain C39217-R109-7 (ATCC-53791), or a BMY-42448-producing mutant or variant thereof, in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under submerged aerobic conditions until a substantial amoung of BMY-42448 is produced by said organism in said culture medium and then recovering the BMY-42448 from the culture medium.