Process for preparing 2,5-dibromopyrimidine

Abstract

Process for preparing 2,5-dibromopyrimidine A process for preparing 2,5-dibromopyrimidine comprises reacting 5-bromo-2-chloropyrimidine with a solution of hydrogen bromide in a non-aqueous acid at a temperature of between 0° and 120° C. The process can be carried out at low cost and gives high yields.

We claim: 
     
       1. Process for the preparation of 2,5-dibromopyrimidine comprising the step of reacting 5-bromo-2-chloropyrimidine with a solution of hydrogen bromide in a non-aqueous acid at a temperature within the range of between 0° to 120° C. 
     
     
       2. Process as claimed in claim 1, wherein the nonaqueous acid is a corboxylic acid. 
     
     
       3. Process as claimed in claim 2, wherein the carboxilic acid is an alcanoic acid. 
     
     
       4. Process as claimed in claim 3, wherein the alcanoic acid is formic acid. 
     
     
       5. Process as claimed in claim 3, wherein the alcanoic acid is acetic acid. 
     
     
       6. Process as claimed in claim 3, wherein the alcanoic acid is propionic acid. 
     
     
       7. Process as claimed in claim 3, wherein the alcanoic acid is trifluoroacetic acid. 
     
     
       8. Process as claimed in claim 1, wherein the reaction temperature lies within the range of between 20° and 70° C. 
     
     
       9. Process as claimed in claim 8, wherein the reaction temperature lies within the range of between 30° and 50° C.