US5382527AExpiredUtility

Transposable elements from streptomyces and other organisms

29
Assignee: LILLY CO ELIPriority: Sep 30, 1988Filed: Oct 18, 1993Granted: Jan 17, 1995
Est. expirySep 30, 2008(expired)· nominal 20-yr term from priority
C12N 15/76C12N 15/00
29
PatentIndex Score
0
Cited by
29
References
11
Claims

Abstract

A novel method for isolating transposable elements was used to isolate an approximately 1.6 kb insertion sequence from Streptomyces. The method entails transforming a cell with a plasmid containing a repressor gene, so that the introduction of a transposable element into the gene allows the expression of a selectable marker in a second host cell. The novel insertion sequence isolated from Streptomyces lividans CT2 has been designated IS493.

Claims

exact text as granted — not AI-modified
I claim: 
     
       1. A recombinant DNA compound comprising the transposable element IS493, wherein one strand of the DNA sequence comprises:   ______________________________________                                    
5'-AGCGTTTTCC                                                             
            ATCCTCAAGC    TGAGCTGGCC                                      
TGATGCAGGC  AGAGGACGGC    CTGGACGAGG                                      
ACCGTGACGC  GGGTGGTCGA    GCAACGGAGC                                      
CTGCGAAGGA  GTCGCCAGGA    CTTGAGGGTC                                      
GCGACGGCTT  GCTCGACGAG    CGCCCGGATC                                      
TTCGCGTGGG  ATCGATTGAC    GGCCTGCTGC                                      
CCTGCAGAGA  GCGTCTCCCA    CCGGCCGCGG                                      
TAGGGAACAC  GGACCGTGCC    TCCGGCGCCC                                      
TGGTAGCCCT  TGTCTGCCCA    GCAGTTGACG                                      
TCGGCTGTGG  CAAGCGTGTC    GATGATGCCG                                      
TGCTCGCGGG  CCGCACGGAC    GTCGTGGACG                                      
GCTCCGGGCA  GGGCCGGCGA    GGCCCACAGC                                      
AGGCGGCCGG  AAGGATCTGC    GATCACCTGT                                      
ACGTTCATCC  CGTGTTTCTT    GTGCTTGCCC                                      
GAGTAGAAAG  GCCGGTCGGC    GGCGATTCGG                                      
TCGATCGGCA  GCAGCGTCCC    GTCCAGCAGG                                      
ACGAACGCCT  TCATCGACGC    CGCCCGGACC                                      
GCCTCGGCGA  GCGTCGGGGC    AAGGGCGGCC                                      
AGAACCTCAG  CTGCCTCGGT    GACGTAGCGG                                      
TAGGCAGTGG  TGGTGCCCAC    GCCGAACCCG                                      
GCCGCGAGCT  GCACATACGG    ATGACCGTTG                                      
CGGAGATGGG  CGAGGGCGAG    CAGAGCCTGC                                      
CGACCTGCGC  TCAGGCGCCG    CCACCGGGTG                                      
CCGAGACCAC  GGCGGTGTTC    CCGCAGACGG                                      
GCGGAGAGGA  AGCGGAGGGC    AGAACTGGAC                                      
ACGTCCAGCC  CGGAGGGGTA    AACAAGCACG                                      
TGAAGCCTCT  AGTAGAGACG    GATTTCTTGG                                      
TCGAAAACCC  ATCTACCAGG    GGCTTCACCC                                      
CTGTGTCAGG  CCAACCCGCA    AGCTGCCGAA                                      
GCAGAATGAA  GACGCTCCTT    GGCTACCGGT                                      
CTGGCGCATG  CGAACCCCGA    CGTCGTGGGT                                      
CTAGCTGGTT  GTCCTGACGG    GTGCGCTGCT                                      
GCGCCCGTGG  CGTCGACCGC    TGAGCTCGGC                                      
GTCGAGTGTC  TCCTGAGCCA    CGCGCATGGC                                      
CTCGGCGTAT  ACGGGGTCCT    GCAGCCGCTT                                      
CCACATCTCG  CCCTCAGAGA    CGICCTCAAC                                      
GCAGCTGACC  ACCCACCAGA    TATTGCCGAA                                      
GGGGTCCTTG  ATGCGCCCTC    CGCGCTGTCC                                      
GAAGGCGTCG  TCGGCCAGGG    AAGTGACGAC                                      
ATAGCCGCCA  GCTGCGACGG    CCTGGGAAAA                                      
CGCCTCGTCC  GCATCGGCGA    CAAATACGCG                                      
CAGCAGGCTC  GGCATGGCGG    GCCAGTCCGT                                      
GTGTCGGTCG  AAGGCCAACA    CGACGGTGTC                                      
GCCGACTCGG  ATCTCAGCGT    GACCGATCAA                                      
GCCCTCCTCG  GTCGACACCC    GCCCGAGTTC                                      
CTCGCCCCCG  AATGCCTGGG    TGACGAAGTC                                      
GAGGAAAGCC  CCCGTGTCGT    CGGTGACGAC                                      
CCAGGGCGCA  ACGGTGGTGT    AGCCCTCCGG                                      
CTCGGGGCTG  GTCTGCTGGG    GCATCGCGGT                                      
CCTTTCGCTG  ATGTTGCTTG    CCAGCAGCGA                                      
CGGTAGGCGT  GAGCTAGGGT    CAGCTTCTGT                                      
CCTAGACGGC  AGTGAGCTTC    GAGCGCAACC                                      
GGTACTACCT  CACGACCGCT    CGCGCTGATC                                      
CAGACCCCGC  CTCTGACCCC    TGACCCCGTC                                      
AGCCTGAGGT  TGAAAAACGC    T-3'                                            
______________________________________                                    
     wherein   A is deoxyadenyl   C is deoxycytidyl   G is deoxyguanyl, and   T is thymidyl.   
     
     
       2. A recombinant DNA cloning vector which comprises the IS493 sequence of claim 1. 
     
     
       3. The recombinant DNA cloning vector of claim 2 which is a phage. 
     
     
       4. The recombinant DNA cloning vector of claim 2 which is a plasmid. 
     
     
       5. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA141. 
     
     
       6. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA150. 
     
     
       7. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA151. 
     
     
       8. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA152. 
     
     
       9. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA153. 
     
     
       10. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA154. 
     
     
       11. The recombinant DNA cloning vector of claim 4 that is plasmid pCZA155.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.