Aminomethyl-benzodioxane and benzopyran serotonergic agents

Abstract

Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.

We claim: 
     
       1. The compound of Formula I or a pharmaceutically acceptable salt, amide or hydrate thereof: ##STR9## wherein: n is 1,2 or 3; Cy is either ##STR10##  (m=0,1 or 2), with the phenyl substituent at the 1 position of the cycloalkanyl or cycloalkenyl ring and the amino substituent at the 4 position; and   R 3  and R 4  are independently H or C 1-4  alkyl.   
     
     
       2. The compound of claim 1 wherein n=1 or 2. 
     
     
       3. The compound of claim 2 wherein R 3  and R 4  are independently hydrogen, methyl or ethyl. 
     
     
       4. The compound(±)Cis-4-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]amino]-1-(1,3-benzodioxol-5-yl)-cyclohexanol. 
     
     
       5. A pharmaceutical composition comprising an effective anxiolytic amount of a compound of claim 1 and a pharmaceutically acceptable carrier. 
     
     
       6. The composition of claim 5 wherein the compound is (±)-Cis-4-[[(3,4-dihydro-2H-1-benzopyran-2yl)methyl]amino]-1-(1,3-benzodioxol-5-yl)-cyclohexanol.   
     
     
       7. A method of treating anxiety comprising administering to a patient in need thereof an effective amount of a compound of claim 1. 
     
     
       8. The method of claim 7 wherein the compound is (±)-Cis-4-[[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]amino]-1-(1,3-benzodioxol-5-yl)-cyclohexanol.