5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes

Abstract

The invention relates to 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes, to processes for their preparation and to their use as inhibitors of reverse transcriptase and in particular as antiretroviral agents.

We claim: 
     
       1. 5,6-Dihydro-dibenz[b ,e]azepine-6,11-dione-11-oximes of the formula (I): ##STR17## in which A, B and D are indentical or different and represent hydrogen, amino, nitro, halogen, cyano, hydroxyl, trifluoromethyl, trifluoromethoxy or straight-chain or branched alkyl or alkoxy each having up to 8 carbon atoms; E represents hydrogen or staight-chain or branched alkyl having up to 6 carbon atoms; and   R 1  represents cycloalkyl having 3 to 6 carbon atoms; or represents 2-tetrahydropyranyl; or   represents straight-chain or branched acyl having up to 8 carbon atoms; or   represents straight-chain or branched alkyl having up to 10 carbon atoms which is substituted by halogen, hydroxyl, carboxyl, straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or by phenyl which is optionally substituted up to 5 times by identical or different halogen atoms; or   represents straight-chain or branched alkenyl having up to 10 carbon atoms which is optionally substituted by halogen, hydroxyl, carboxyl, straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or by phenyl which is optionally substituted up to 5 times by identical or different halogen atoms; if appropriate in an isomeric form, or a physiologically acceptable salt thereof.       
     
     
       2. A compound according to claim 1, wherein such compound is selected from the group consisting of: ##STR18## 
     
     
       3. 5,6-Dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes of the formula (I): ##STR19## in which A, B and D are indentical or different and represent amino, nitro, cyano, hydroxyl, trifluoromethyl or trifluoromethoxy; E represents hydrogen or staight-chain or branched alkyl having up to 6 carbon atoms; and   R 1  represents hydrogen; or represents cycloalkyl having 3 to 6 carbon atoms; or   represents 2-tetrahydropyranyl; or   represents straight-chain or branched acyl having up to 8 carbon atoms; or   represents straight chain or branched alkyl having up to 10 carbon atoms which is optionally substituted by halogen, hydroxyl, carboxyl, straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or by phenyl which is optionally substituted up to 5 times by identical or different halogen atoms; or   represents straight-chain or branched alkenyl having up to 10 carbon atoms which is optionally substituted by halogen, hydroxyl, carboxyl, straight-chain or branched alkoxycarbonyl having up to 6 carbon atoms, or by phenyl which is optionally substituted up to 5 times by identical or different halogen atoms; if appropriate in an isomeric form, or a physiologically acceptable salt thereof.