Combination of pyrimidine derivatives and of salicylic acid derivatives for inducing and stimulating the growth of hair and reducing its loss

Abstract

The combination comprises: a) a component (A) containing a pyrimidine derivative of formula: <IMAGE> (I) in which R1 denotes <IMAGE> in which R3 and R4 denote hydrogen, alkyl, alkenyl, alkylaryl or cycloalkyl, R3 and R4 may also form a heterocyclic ring with the nitrogen atom to which they are linked, R2 is hydrogen, alkyl, alkenyl, alkoxyalkyl, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl or haloarylalkyl; and b) a component (B) containing a salicylic acid derivative. The components (A) and (B) forming part of the same single composition or being intended to be employed separately, either simultaneously or successively or at intervals of time, on the hair and the scalp.

We claim: 
     
       1. A combination of components, which is useful for the treatment of the hair and scalp and is effective for inducing and stimulating hair growth and for decreasing hair loss, comprising: (a) a first component (A), comprising a composition containing a physiologically acceptable medium and 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine or minoxidil; and   (b) a second component (B), comprising a composition containing a physiologically acceptable medium and 5-n-octanoyl salicylic acid, wherein said components are intended for use as a composition comprising said components or as separate components that are used either simultaneously, successively or intermittently; and wherein minoxidil consists of between 0.05 and 10% by weight of component (A), and 5-n-octanoyl salicylic acid consists of between 0.05 and 10% by weight of component (B).   
     
     
       2. The combination of claim 1, wherein minoxidil is between 0.05 and 5% by weight of component (A). 
     
     
       3. The combination of claim 1, wherein the weight ratio of minoxidil to 5-n-octanoylsalicylic acid is between 1 and 10. 
     
     
       4. The combination of claim 1, wherein said physiologically acceptable medium is selected from the group consisting of a mixture of water and one or more organic solvents, and a mixture of pharmaceutically or cosmetically acceptable organic solvents. 
     
     
       5. The combination of claim 4, wherein said solvents are selected from the group consisting of C 1  -C 4  lower alcohols, alkylene glycols, and mono- and dialkylene glycol alkyl ethers. 
     
     
       6. The combination of claim 1, wherein the physiologically acceptable medium of at least one of components (A) and (B) is thickened by the addition of thickening agents, gelling agents, or both thickening and gelling agents. 
     
     
       7. The combination of claim 1 further comprising in either or both of said components (A) and (B) at least one cosmetically or pharmaceutically acceptable adjuvant selected from the group consisting of preserving agents, complexing agents, colorants, alkalifying agents, acidifying agents, anionic agents, nonionic agents, amphoteric surface-active agents, mixtures of anionic, nonionic, and amphoteric surface-active agents, anionic polymers, cationic polymers, nonionic polymers, amphoteric polymers, and mixtures of anionic, cationic, nonionic and amphoteric polymers. 
     
     
       8. A multicompartment device or kit or outfit comprising component (A) of claim 1 in a first compartment and component (B) of claim 1 in a second compartment. 
     
     
       9. A medicament for the treatment of alopecia consisting of the combination of claim 1 and a carrier suitable for topical application of said medicament to the hair or scalp. 
     
     
       10. A process for the preparation of a medicament for the treatment of alopecia comprising mixing the combination of claim 1 with a carrier that is suitable for the topical application of said medicament to the hair or scalp. 
     
     
       11. The combination of claim 1 comprising a composition containing components (A) and (B).