Methods for inhibiting vascular smooth muscle cell proliferation and restinosis

Abstract

Methods of inhibiting vascular smooth muscle cell proliferation and vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula <IMAGE> (I) or <IMAGE> (II) wherein R1 and R3 are independently hydrogen, -CH3, <IMAGE> wherein Ar is optionally substituted phenyl; R2 is <IMAGE> R4 is hydrogen or -OR1, and pharmaceutically acceptable salts and solvates thereof.

We claim: 
     
       1. A method of inhibiting vascular smooth muscle cell proliferation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR8## wherein R 1  and R 3  are independently hydrogen, --CH 3 , ##STR9## wherein Ar is optionally substituted phenyl; ##STR10## R 4  is hydrogen or --OR 1 , and pharmaceutically acceptable salts and solvates thereof. 
     
     
       2. The method of claim 1 wherein said compound is the hydrochloride salt thereof. 
     
     
       3. The method of claim 1 wherein said administration is prophylactic. 
     
     
       4. The method of claim 1 wherein said compound is ##STR11## or its hydrochloride salt. 
     
     
       5. A method of inhibiting vascular restinosis comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR12## wherein R 1  and R 3  are independently hydrogen, --CH 3 , ##STR13## wherein Ar is optionally substituted phenyl; R 2  is ##STR14## and R 4  is hydrogen or --OR 1 , and pharmaceutically acceptable salts and solvates thereof. 
     
     
       6. The method of claim 5 wherein said compound is the hydrochloride salt thereof. 
     
     
       7. The method of claim 5 wherein said administration is prophylactic. 
     
     
       8. The method of claim 5 wherein said compound is ##STR15## or its hydrochloride salt.