Artificial antibody

Abstract

This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.

What we claim is: 
     
       1. An isolated DNA coding for a constant region of a human immunoglobulin IgG H-chain polypeptide which contains an RGDS amino acid sequence and has cell adhesive activity, wherein said DNA has the sequence of SEQ. ID. No. 4 and is obtained from Escherichia coli HB 101/CT2 (FERM BP-3399). 
     
     
       2. An isolated DNA coding for a constant region of a human immunoglobulin IgG H-chain polypeptide which contains an RGDS amino acid sequence and has cell adhesive activity, wherein said DNA has the sequence of SEQ. ID. No. 4.