2',3'-dideoxynucleoside pyrimidine compounds and carbocyclic analogs

Abstract

2',3'-dideoxynucleoside pyrimidine compounds and 2-thiothymidine carbocyclic derivatives with antiviral activity are disclosed. These compounds are expected to exhibit antiviral activity recognized for 2',3'-dideoxynucleoside compounds and analogs thereof.

We claim: 
     
       1. A substituted pyrimidine nucleoside selected from the group consisting of: 1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-5-methyl-pyrimidine-2-one,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-thiothymine,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-hydroxylamino-5-methyl-(1H)-pyrimidine-2-one,   5-chloro-1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-thiouracil,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-(1H)-pyrimidine-2-one,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-thiouracil,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-hydroxylamino-(1H)-pyrimidine-2-one,   1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-4-thiothymine,   1-(2,3-dideoxy-βD-glycero-pent-2-enofuranosyl)-5-methyl-(1H)-pyrimidine-2-one,   1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-4-hydroxylamino-(1H)-pyrimidine-2-one,   1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-4-dimethylamino-(1H)-pyrimidine-2-one,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-5-methyl-pyrimidine-2-one,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-pyrimidine-2-one,   2',3'-dideoxy-2',3'-didehydro-4-thiothymidine,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2-thiothymine,   1-(5-O-acetyl-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2-thiothymine,   1-(5-O-acetyl-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2,4-dithiothymine,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-2,4-dithiothymine,   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-5-ethyl-4-thiouracil,   (±)-1-[1β,3,4β)-3-fluoro-4-(trityloxymethyl)-cyclopentyl]-2-thiothymine,   (±)-1-[1β,3α,4β)-3-fluoro-4-(hydroxymethyl)-cyclopentyl]-2-thiothymine,   3'-deoxy-4-thiothymidine,   1-(5-O-acetyl-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-thiothymine,   1-(5-O-acetyl-2,3-dideoxy-3-fluoro-β-D-glycero-ribofuranosyl)-4-hydroxylamino-(1H) pyrimidine-2-one,   1-(2,3-dideoxy-3-fluoro-β-D-glycero-ribofuranosyl)-4-hydroxylamino-(1H)-pyrimidine-2-one,   1-(5-O-acetyl-2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-hydroxylamino-5-methyl-(1H)-pyrimidine-2-one,   1-(5-O-acetyl-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-4-thiothymine, and   1-(2,3-dideoxy-3-fluoro-β-D-ribofuranosyl)-4-thiothymine-5'-triphosphate.