Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.

Abstract

The invention involves thromboembolically effective compositions and therapeutic methods. Thrombolytically active proteins are combined with anticoagulants, as long as the anticoagulant is not heparin. The anticoagulant is administered in an intravenous bolus form, while the thrombolytically active protein may be administered via intravenous bolus, or intravenous infusion.

We claims: 
     
       1. Method for treating a subject in need of thrombolytic therapy, comprising administering to said subject an effective amount of: (i) BM 06.022, which consists of SEQ ID NO: 1 and   (ii) via bolus injection, hirudin.   
     
     
       2. The method of claim 1, wherein said BM 06.022 is administered intravenously. 
     
     
       3. The method of claim 1, wherein said BM 06.022 is administered in bolus form. 
     
     
       4. The method of claim 1, wherein said BM 06.022 is administered in more than one bolus. 
     
     
       5. The method of claim 4, wherein said boli are administered to said patient about 30 minutes apart. 
     
     
       6. The method of claim 1, further comprising administering a non-aspirin, antiplatelet agent. 
     
     
       7. The method of claim 1, further comprising administering heparin to said subject. 
     
     
       8. The method of claim 5, wherein said two boli comprise doses of 10 MU of BM 06.022. 
     
     
       9. The method of claim 7, wherein said heparin is administered via intravenous infusion, or subcutaneously. 
     
     
       10. The method of claim 7, wherein said heparin is administered 1-2 hours after administration of hirudin.