US5541298AExpiredUtilityPatentIndex 49

Method of determining metastatic potential of tumor cells

Assignee: MICHIGAN CANCER FOUNDATIONPriority: Jul 14, 1992Filed: Jun 2, 1995Granted: Jul 30, 1996

Est. expiryJul 14, 2012(expired)· nominal 20-yr term from priority

Inventors:RAZ AVRAHAM NABI IVAN R WATANABE HIDEOMI OTTO THOMAS

G01N 33/57525G01N 33/5759G01N 2333/705Y10S436/813Y10S530/828C07K 14/705G01N 33/5758G01N 2800/34G01N 33/68G01N 33/5754

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Abstract

Methods and compositions useful in the detection of human cancer cells and malignant tumors are provided. Certain human autocrine motility factor receptors or proteins (gp78-hAMFR) have been identified which are useful in the detection of human cancer cells and malignant tumors. Methods and assay kits for the detection of human cancer, human cancer cells, and tumors, are provided wherein antibodies or other probes are used which recognize gp78-hAMFR expression. These methods and assay readily distinguish between non-malignant and malignant cancer cells and tumors and can be used to gauge metastatic potential.

Claims

exact text as granted — not AI-modified

What is claimed is: 
     
       1. A purified and isolated human autocrine motility factor receptor having the amino acid sequence set forth in FIG. 1, SEQ ID NO. 1. 
     
     
       2. A polypeptide having the amino acid sequence of amino acids 1 to 111 in FIG. 1, SEQ ID NO. 1.

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