Preparation for skin and mucous membrane

Abstract

By reacting 1-5.5M nitric acid with from 45 to 170 mmol of primary C 1 -C 5 -alkanol per l of nitric acid, an improved preparation is obtained for the local treatment of changes in skin and mucous membrane and of infections of the skin and mucous membrane. The preparation comprises 1-5.5M nitric acid, not more than 170 mmol of C 1 -C 5 -alkanoic acid per l of solution, and nitrate reduction products in a concentration corresponding to from 0.1 to 6 mg of nitrite per ml of solution. The preparation is notable for a good activity and a low risk of side effects.

We claim: 
     
       1. A stable and reproducible composition based on an aqueous solution of nitric acid, containing nitrate reduction products, for the local treatment of superficial changes in skin and mucous membrane and of superficial infections of the skin and mucous membrane, characterized in that said composition consists essentially of 1-5.5M aqueous nitric acid, nitrate reduction products in a concentration corresponding to from 0.1 to 6 mg of nitrite per ml of solution, and C 1  -C 5  -alkanoic acid in a concentration of not more than 170 mmol per l of solution, said composition being enclosed in a container with a gastight closure and having constant concentrations of the nitric acid, nitrate reduction products and alkanoic acid which are essentially independent of temperature and storage time. 
     
     
       2. The composition according to claim 1 for the treatment of hyperplastic changes in skin and mucous membrane, characterized in that it has a nitric acid concentration of 4-5.5M. 
     
     
       3. The composition according to claim 1 for the treatment of fungal diseases of the skin and mucous membrane, characterized in that it has a nitric acid concentration of 1-4M. 
     
     
       4. The composition according to one of claims 1 to 3, characterized in that the concentration of nitrate reduction products corresponds to from 1 to 5 mg of nitrite per ml of solution. 
     
     
       5. The composition according to claim 4, characterized in that the concentration of nitrate reduction products corresponds to from 2 to 4 mg of nitrite per ml of solution. 
     
     
       6. The composition according to claim 1, characterized in that the concentration of C 1  -C 5  -alkanoic acid is at least 5 mmol per l. 
     
     
       7. The composition according to claim 6, characterized in that the concentration of C 1  -C 5  -alkanoic acid is from 9 to 90 mmol per l. 
     
     
       8. The composition according to claim 1, characterized in that it contains acetic acid as C 1  -C 5  -alkanoic acid. 
     
     
       9. The composition according to claim 1, characterized in that the composition is enclosed in a sealed ampoule. 
     
     
       10. The composition according to claim 1, characterized in that the ratio of the liquid volume to the total volume of the container is not more than 1:2. 
     
     
       11. The composition according to claim 10, characterized in that the ratio of the liquid volume to the total volume of the container is from 1:10 to 1:5. 
     
     
       12. Process for the production of a composition according to claim 1, characterized in that 1-5.5 M aqueous nitric acid is reacted with a primary C 1  -C 5  -alkanol in a quantity of from 45 to 170 mmol per 1 of nitric acid. 
     
     
       13. Process according to claim 12, characterized in that from 60 to 90 mmol of the primary C 1  -C 5  -alkanol are used per 1 of nitric acid. 
     
     
       14. Process according to claim 12 or 13, characterized in that ethanol is used as primary C 1  -C 5  -alkanol. 
     
     
       15. Process according to claim 12 or 13, characterized in that the nitric acid and the primary C 1  -C 5  -alkanol are mixed at a temperature below the reaction temperature and the mixture in a container with a gastight closure, is heated to reaction temperatue or above. 
     
     
       16. Process according to claim 15, characterized in that the nitric acid is mixed with ethanol at a temperature of not more than 10° C. and the mixture in a container with a gastight closure is heated to from 20° to 40° C. 
     
     
       17. Process according to claim 15, characterized in that the gastight closure is a sealed ampoule. 
     
     
       18. Process according to claim 16, characterized in that the mixture is heated to room temperature.