Use of cyanoacrylate adhesives for providing a protective barrier film for the skin

Abstract

A cyanoacrylate adhesive is applied onto skin area prone to exposure to discharge by patients suffering from incontinence so as to shield the skin from direct contact with the discharge. The adhesive can also be applied over medicament that has been applied onto skin surface and onto skin along the periphery of a stoma.

What is claimed is: 
     
       1. A method for shielding a patient's skin from urine or fecal wastes caused by incontinence, which method comprises: applying to a surface skin area which comes in contact with such urine or fecal wastes a sufficient amount of a cyanoacrylate adhesive to cover said area from said urine and/or fecal wastes; and   polymerizing the cyanoacrylate adhesive so as to form a flexible, waterproof, adhesive polymer coating which adheres to the area where the adhesive was applied,   wherein the cyanoacrylate, in monomeric form, is represented by formula I: ##STR6## where R is selected from the group consisting of: alkyl of 2 to 10 carbon atoms,   alkenyl of 2 to 10 carbon atoms,   cycloalkyl groups of from 5 to 8 carbon atoms,   phenyl,   2-ethoxyethyl,   3-methoxybutyl,   and a substituent of the formula: ##STR7## wherein each R' is independently selected from the group consisting of: hydrogen and methyl, and R" is selected from the group consisting of:     alkyl of from 1 to 6 carbon atoms,   alkenyl of from 2 to 6 carbon atoms,   alkynyl of from 2 to 6 carbon atoms,   cycloalkyl of from 3 to 8 carbon atoms,   aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,   phenyl, and   phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms.   
     
     
       2. A method according to claim 1 wherein R is alkyl of from 2 to 8 carbon atoms. 
     
     
       3. A method according to claim 2 wherein R is butyl, pentyl or octyl. 
     
     
       4. A method according to claim 3 wherein R is n-butyl or isobutyl. 
     
     
       5. A method according to claim 1 wherein said adhesive is applied in an amount of at least 0.02 ml of cyanoacrylate adhesive per square centimeter of skin which is to be covered. 
     
     
       6. A method according to claim 5 wherein the cyanoacrylate adhesive is applied in an amount of from about 0.02 ml to about 0.2 ml per square centimeter of skin. 
     
     
       7. A method according to claim 6 wherein the cyanoacrylate adhesive is applied in an amount of from about 0.02 ml to about 0.1 ml per square centimeter of skin. 
     
     
       8. A method according to claim 1 wherein the cyanoacrylate adhesive has a viscosity of from greater than 2 to about 3000 centipoise at 20° C. 
     
     
       9. A method according to claim 8 wherein the cyanoacrylate adhesive has a viscosity of from greater than 2 to about 100 centipoise at 20° C. 
     
     
       10. A method according to claim 1 wherein the cyanoacrylate adhesive is applied from a single use applicator. 
     
     
       11. A method according to claim 1 wherein, prior to applying the cyanoacrylate adhesive onto the surface skin area, the method comprises of applying a bacteriostat onto the surface skin area. 
     
     
       12. A method for providing a protective covering over a medicament on a patient, which method comprises: applying a medicament onto the skin:   applying onto said medicament and onto surface skin along the periphery of said medicament, a sufficient amount of a cyanoacrylate adhesive so as to cover said medicament and surface skin; and   polymerizing the cyanoacrylate adhesive so as to form a flexible, waterproof, adhesive polymer coating which adheres to the surface skin where the adhesive was applied,   wherein the cyanoacrylate, in monomeric form, is represented by formula I: ##STR8## where R is selected from the group consisting of: alkyl of 2 to 10 carbon atoms,   alkenyl of 2 to 10 carbon atoms,   cycloalkyl groups of from 5 to 8 carbon atoms,   phenyl,   2-ethoxyethyl,   3-methoxybutyl,   and a substituent of the formula: ##STR9## wherein each R' is independently selected from the group consisting of: hydrogen and methyl, and R" is selected from the group consisting of:     alkyl of from 1 to 6 carbon atoms,   alkenyl of from 2 to 6 carbon atoms,   alkynyl of from 2 to 6 carbon atoms,   cycloalkyl of from 3 to 8 carbon atoms,   aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,   phenyl, and   phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms.   
     
     
       13. A method according to claim 12 wherein R is alkyl of from 2 to 8 carbon atoms. 
     
     
       14. A method according to claim 13 wherein R is butyl, pentyl or octyl. 
     
     
       15. A method according to claim 14 wherein R is n-butyl or isobutyl. 
     
     
       16. A method for providing a protective covering on skin along the periphery of a patient's stoma which method comprises: applying onto said skin along the periphery of the stoma a sufficient amount of a cyanoacrylate adhesive so as to cover said skin; and   polymerizing the cyanoacrylate adhesive so as to form a flexible, waterproof, adhesive polymer coating which adheres to the skin surface where the adhesive was applied,   wherein the cyanoacrylate, in monomerie form, is represented by formula I: ##STR10## where R is selected frown the group consisting of: alkyl of 2 to 10 carbon atoms,   alkenyl of 2 to 10 carbon atoms,   cycloalkyl groups of from 5 to 8 carbon atoms,   phenyl,   2-ethoxyethyl,   3-methoxybutyl, and a substituent of the formula: ##STR11## wherein each R' is independently selected from the group consisting of: hydrogen and methyl, and   R" is selected from the group consisting of:     alkyl of from 1 to 6 carbon atoms,   alkenyl of from 2 to 6 carbon atoms,   alkynyl of from 2 to 6 carbon atoms,   cycloalkyl of from 3 to 8 carbon atoms,   aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,   phenyl, and   phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms.   
     
     
       17. A method according to claim 16 wherein R is alkyl of from 2 to 8 carbon atoms. 
     
     
       18. A method according to claim 17 wherein R is butyl, pentyl or octyl. 
     
     
       19. A method according to claim 18 wherein R is n-butyl or iso-butyl.