6-amino-1,2-benzopyrones useful for treatment of viral diseases

Abstract

Unsubstituted or substituted 6-amino-1,2-benzopyrones are potent, selective and non-toxic inhibitors and suppressants of viral infections in a mammalian host. The compounds are particularly useful for treatment of AIDS, herpetic episodes and cytomegaloviral infections. The method of treatment of viral diseases by 6-amino-1,2-benzopyrones is described.

We claim: 
     
       1. A method of inhibiting viral growth and replication within a cell in the substantial absence of cellular toxicity comprising contacting a cell selected from the group consisting of human immunodeficiency virus, herpes simplex virus type 1, herpes simplex virus type 2 and cytomegalovirus with an effective amount of a compound or salt thereof, having the formula: ##STR7## in combination with an effective amount of an inert carrier wherein R 1 , R 2 , R 3 , R 4 , or R 5  are, independent from one another, selected from the group consisting of hydrogen, hydroxy, amino, (C 1  -C 6 ) alkyl, (C 1  -C 5 ) alkoxy, (C 3  -C 8 ) cycloalkyl, phenyl, phenyl substituted with alkyl, alkoxy, hydroxy, or halogen. 
     
     
       2. The compound of claim 1 wherein R 1 , R 2 , R 3 , R 4  or R 5  are hydrogen. 
     
     
       3. The method of claim 1, wherein the virus is human immunodeficiency virus. 
     
     
       4. The method of claim 1, wherein the virus is herpes simplex virus type 1 or type 2. 
     
     
       5. The method of claim 1, wherein the virus is cytomegalovirus. 
     
     
       6. The method of claim 1, wherein the cell is in a subject in need of an anti-viral treatment. 
     
     
       7. The method of claim 1 wherein the composition is administered by intravenous injection. 
     
     
       8. The method of claim 6 wherein the composition is administered in amount of 0.1 to 100 mg/kg/day. 
     
     
       9. A method of inhibiting viral growth and replication within a cell in the substantial absence of cellular toxicity comprising contacting a cell selected from the group consisting of human immunodeficiency virus, herpes simplex virus type 1, herpes simplex virus type 2 and cytomegalovirus with effective amount of a compound having the formula: ##STR8## wherein R 1 , R 2 , R 3 , R 4 , or R 5  are, independent from one another, selected from the group consisting of hydrogen, hydroxy, amino, (C 1  -C 6 ) alkyl, (C 1  -C 5 ) alkoxy, (C 3  -C 8 ) cycloalkyl, phenyl, phenyl substituted with alkyl, alkoxy, hydroxy, or halogen.