US5672625AExpiredUtility

Sulfonic stilbene derivatives in the treatment of viral diseases

65
Assignee: MERRELL PHARMA INCPriority: Feb 5, 1991Filed: Jun 5, 1995Granted: Sep 30, 1997
Est. expiryFeb 5, 2011(expired)· nominal 20-yr term from priority
Inventors:Alan D. CardinA. Stanley Tyms
A61K 31/185A61P 31/18A61P 31/22A61P 31/12A61K 31/26C07C 331/30A61K 31/275C07C 331/28A61K 31/10
65
PatentIndex Score
22
Cited by
45
References
4
Claims

Abstract

Sulfonic acid stilbenes block the infection of cells by HSV and CMV and these compounds can be used to treat viral infection.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method of treating a viral infection selected from HSV and CMV, in a patient in need thereof comprising administering to the patient an antivirally effective amount of a compound of the formula ##STR6## wherein R 1  and R 2  are each independently a S═C═N-- or CH 3  C(O)N H-- group, B is a --CH 2  --CH 2  -- group, and   M 1  and M 2  are each independently a hydrogen or pharmaceutically acceptable cation.   
     
     
       2. A method of claim 1 wherein the sulfonyl groups are at the ortho position. 
     
     
       3. A method of claim 1 wherein M 1  and M 2  are each independently a hydrogen or a sodium cation. 
     
     
       4. A method of claim 1 wherein the compound is 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid.

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