5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular disease

Abstract

The use of 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for treating ocular diseases with immune etiology is disclosed.

We claim: 
     
       1. A method for treating uveitis, which comprises: administering a therapeutically effective amount of a compound with the formula: ##STR5## in which R 1 , R 2  and R 3 , which may be identical or different, each stands for an alkyl group of 1, 2, 3 or 4 carbon atoms, an alkoxy group of 1, 2 or 3 carbon atoms, an alkylthio group of 1, 2 or 3 carbon atoms, which groups may be substituted entirely or partly by identical or different halogen atoms, such as fluorine, chlorine, bromine or iodine; for a nitro, cyano or alkoxycarbonyl group of 1, 2 or 3 carbon atoms in the alkyl moiety; R 1  and R 2  each further stands for hydrogen, in which case, however, R 3  cannot stand for methyl but additionally stands for a phenyl group which may carry one or two fluorine, chlorine, bromine or iodine atoms, alkyl groups of 1, 2 3 or 4 carbon atoms, or alkoxy groups of 1, 2 or 3 carbon atoms, or for a phenoxy group which may carry one or two fluorine, chlorine, bromine or iodine atoms, alkyl groups of 1, 2 or 3 carbon atoms or alkoxy groups of 1, 2 or 3 carbon atoms, or R 1  stands for hydrogen, and R 2  and R 3  together stand for a methylene-dioxy group, or together with the phenyl ring, to which they are linked, they stand for a naphthalene ring, and in which M stands for hydrogen, an alkali metal, such as sodium or potassium, or ammonium.   
     
     
       2. The method of claim 1 wherein the compound is delivered at a concentration of between about 0.0001-30 mg/kg/day. 
     
     
       3. The method of claim 1 wherein the compound is delivered systemically at a concentration of about 0.01-10.0 mg/kg/day. 
     
     
       4. The method of claim 1 wherein the compound is delivered topically to the eye at a concentration of about 0.05-10.0 wt. %. 
     
     
       5. A method for treating uveitis, which comprises: administering a therapeutically effective mount of a compound with the formula: ##STR6##   
     
     
       6. The method of claim 5 wherein the compound is delivered at a concentration of between about 0.0001-30 mg/kg/day. 
     
     
       7. The method of claim 5 wherein the compound is delivered systemically at a concentration of about 0.01-10.0 mg/kg/day. 
     
     
       8. The method of claim 5 wherein the compound is delivered topically to the eye at a concentration of about 0.05-10.0 wt. %.