N-cinnamoyl-2-methyl-5-methoxy-3-indoleacetic acid ester, and pharmaceutical preparation containing the same

Abstract

The present invention relates to a new N-cinnamoyl-2-methyl-5-methoxy-3-indoleacetic ester represented by the following general formula (I). It is manufactured by causing N-cinnamoyl-2-methyl-5-metboxy-3-indoleacetic acid represented by the following general formula (II) or a reactive derivative thereof to react with a compound represented by the following general formula (III) ##STR1## wherein, R is ##STR2## The inventive compounds are effective to the same extent as the existing cinmetacin, and are also excellent in greatly reducing fatal side effects like a gastric ulcer, that are associated with cinmetacin or an intestinal ulcer.

What is claimed is 
     
       1. A compound represented by the following formula ##STR8## wherein R is ##STR9## 
     
     
       2. A pharmaceutical composition, which comprises: an effective amount of a compound represented by the following formula (I) together with a pharmaceutically acceptable excipient or auxiliary, ##STR10## wherein R is ##STR11##