Method of attenuation of nervous system damage

Abstract

A method is disclosed for attenuation of nervous system damage after injury which comprises administering therapeutic amounts of PREG, PREG-S, or esters of PREG or PREG-S together with an enhancer of secretory processes in non-neural cells such as a bacterial lipopolysaccharide and a non-steroidal antiinflammatory substance such as indomethacin.

We claim: 
     
       1. A method for attenuating physical damage to a spinal cord of a patient and promoting recovery of motor functions, wherein said patient has a trauma of the spinal cord which is less than severing and which is sufficient to cause loss of motor function, comprising the steps of: first administering to said patient a therapeutically effective amount of pregnenolone or pregnenolone sulfate;   second administering to said patient together with said pregenenolone or pregnenolone sulfate provided by said first administering step therapeutically effective amounts of   (I) a substance that stimulates secretion of cytokines by macrophages, and   (II) a non-steroidal antiinflammatory drug,   said pregnenolone or pregnenolone sulfate provided in said first administering step, said substance that stimulates secretion of cytokines provided in said second administering step, and said non-steroidal anti-inflammatory drug administered in said second administering step being sufficient to repair physical damage to said patient's spinal cord and restore motor functions to said patient.   
     
     
       2. The method of claim 1 further comprising the step of selecting said non-steroidal anti-inflammatory drug provided in said second administering step from the group consisting of aspirin, indomethacine ibuprofen, acetaminophen, sodium salicylate, diclofenac, and naproxen. 
     
     
       3. The method of claim 2 wherein said non-steroidal antiinflamatory drug is aspirin. 
     
     
       4. The method of claim 2 wherein said non-steroidal antiinflamatory drug is indomethacin. 
     
     
       5. The method of claim 2 wherein said non-steroidal antiinflamatory drug is naproxen. 
     
     
       6. The method of claim 1 wherein said second step of administering includes the step of injecting said non-steroidal antiinflammatory drug in said patient. 
     
     
       7. The method of claim 1 further comprising the step of selecting said substance that stimulates secretion of cytokines from the group consisting of lipopolysaccharides, ImuVert, muramyl dipeptides, pyran polymers, and dextran polymers. 
     
     
       8. The method of claim 1 wherein said second step of administering includes the step of injecting said substance that stimulates secretion of cytokines in said patient.