US5759552AExpiredUtility

Marek's disease virus recombinant poxvirus vaccine

43
Assignee: VIROGENETICS CORPPriority: Mar 7, 1991Filed: Mar 7, 1994Granted: Jun 2, 1998
Est. expiryMar 7, 2011(expired)· nominal 20-yr term from priority
Inventors:Enzo PaolettiJill TaylorJames TartagliaLouis Joseph Norman Ross
A61K 39/12A61K 2039/5256C12N 2710/16334C12N 2710/24143C12N 7/00C12N 2710/24161A61K 39/255
43
PatentIndex Score
7
Cited by
157
References
14
Claims

Abstract

What is described is a recombinant poxvirus, such as vaccinia virus or fowlpox virus, containing foreign DNA from Marek's disease virus. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A recombinant TROVAC fowlpox comprising exogenous DNA encoding at least one of Marek's Disease Virus gB and gD glycoproteins. 
     
     
       2. The recombinant TROVAC fowlpox virus of claim 1 comprising exogenous DNA encoding Marek's Disease Virus gB glycoprotein. 
     
     
       3. The recombinant TROVAC fowlpox virus of claim 1 comprising exogenous DNA encoding Marek's Disease Virus gD glycoprotein. 
     
     
       4. The recombinant TROVAC fowlpox virus of claim 1 comprising exogenous DNA encoding Marek's Disease Virus gB and gD glycoproteins. 
     
     
       5. The recombinant TROVAC fowlpox virus of claim 1 comprising vFP108. 
     
     
       6. An immunological composition comprising a carrier and a recombinant TROVAC fowlpox virus as claimed in any one of claims 1 to 5. 
     
     
       7. The immunological composition of claim 6 which induces a protective immune response and is thus a vaccine. 
     
     
       8. A method for inducing an immunological response in a host comprising administering a recombinant TROVAC fowlpox virus as claimed in any one of claims 1 to 5. 
     
     
       9. A method for inducing an immunological response in a host comprising administering an immunological composition as claimed in claims 6. 
     
     
       10. A method for inducing an immunological response in a host comprising administering an immunological composition as claimed in claims 7. 
     
     
       11. The method of claim 8 wherein the host is a chicken. 
     
     
       12. The method of claim 9 wherein the host is a chicken. 
     
     
       13. The method of claim 10 wherein the host is a chicken. 
     
     
       14. A method for expressing a gene product in vitro comprising contacting cells with a recombinant TROVAC fowlpox virus as claimed in any one of claims 1 to 5.

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