Percutaneously absorbable patch

Abstract

A percutaneously absorbable preparation-containing patch, wherein the preparation comprises: (1) a base comprising as essential ingredients a (A-B) n-A based elastomer wherein A is substantially a monovinyl-substituted aromatic compound polymer block, B is substantially a conjugated diolefin copolymer block, and n is an integer of 3-7, crotamiton, and a softening agent; and (2) at least two hormones, especially estrogen and luteal hormones, as active ingredients.

We claim: 
     
       1. A percutaneously absorbable preparation-containing patch, wherein the preparation comprises: (1) 20 to 99% by weight of a base comprising as essential ingredients: (a) 5 to 50% by weight of a (A-B) n  -A based elastomer, wherein A is substantially a monovinyl-substituted aromatic compound polymer block, B is substantially a conjugated diolefin copolymer block, and n is an integer of 3-7,   (b) 1 to 20% by weight of crotamiton, and   (c) 10 to 70% by weight of a softening agent; and     (2) 0.01 to 10% by weight of estrogen and 0.01 to 10% by weight of a luteal hormone as active ingredients, the proportion of each ingredient being based on the total amount of the pharmaceutical preparation.   
     
     
       2. A patch according to claim 1, wherein the preparation further contains 5 to 40% by weight of a tackifier. 
     
     
       3. A patch according to claim 1, wherein the preparation further contains at most 15% by weight of a super absorbent polymer. 
     
     
       4. A patch according to claim 1, 2 or 3, wherein the weight ratio of the content of the luteal hormone to the content of the estrogen is 1 to 5. 
     
     
       5. A patch according to claim 1, 2, 3 or 4, wherein the estrogen is estradiol, estrone, equilin, equilenin or a derivative thereof. 
     
     
       6. A patch according to claim 1, 2, 3 or 4, wherein the luteal hormone is progesterone, hydroxy-progesterone caproate, medroxyprogesterone acetate, dydrogesterone, chlormadinone acetate, ethisterone, dimethisterone, norethisterone, norethisterone acetate, norethisterone enanthate, ethynodiol acetate, megestrol acetate or allylestrenol. 
     
     
       7. A patch according to claim 1, 2, 3, 4, 5 or 6, wherein the preparation is in a dosage form of a plaster.