Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation

Abstract

Use of xanthine derivatives for the treatment of nerve damage following an interruption in blood circulation. The invention relates to the use of xanthine derivatives of the formula I ##STR1## in which R 2 is a (C 1 -C 4 )-alkyl group and at least one of the symbols R 1 and R 3 is a radical of the formula II or III ##STR2## in which A is CHOH, CO or dioxolane, R 4 is a hydrogen atom or a (C 1 -C 4 )-alkyl group and n is 0 to 5, and in which R 5 and R 6 are hydrogen atoms or (C 1 -C 4 )-alkyl groups or, together with the nitrogen atom to which they are bonded, form a 5- to 7-membered ring, it being possible for one carbon atom to be replaced by an oxygen or nitrogen atom, m is 1 or 2 and the other radical R 1 or R 3 , if appropriate, is a hydrogen atom, a (C 1 -C 6 )-alkyl group or a (C 3 -C 6 )-alkenyl group, for the preparation of medicaments for the prophylaxis and treatment of nerve damage following an interruption in blood circulation, and novel xanthine derivatives, and to processes for their preparation.

What is claimed is: 
     
       1. A compound of the formula 1-(4,4-ethylenedioxy-3-methylpentyl)-3-methyl-7-propylxanthine. 
     
     
       2. A compound of the formula 1-(4-oxo-3-methylpentyl)-3-methyl-7-allylxanthine. 
     
     
       3. A compound of the formula 1-(4-oxo-3-methylpentyl)-3-ethyl-7-(2-methoxyethyl)-xanthine. 
     
     
       4. A compound of the formula 1-ethoxymethyl-3-methyl-7-dimethylamino-carbonylmethyl-xanthine. 
     
     
       5. A compound of the formula 1,7-bis(piperazinocarbonylmethyl)-3-methylxanthine.