Hmvab41

Abstract

HMVAB41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMVAB41 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammation, autoimmunity, allergy, asthma, rheumatoid arthritis, CNS inflammation, cerebellar degeneration, Alzheimer's disease, Parkison's disease, multiple sclerosis, amylotrophic lateral sclerosis, head injury damage, and other neurological abnormalities, septic shock, sepsis, stroke, osteoporosis, osteoarthritis, ischemia reperfusion injury, cardiovascular disease, kidney disease, liver disease, ischemic injury, myocardial infarction, hypotension, hypertension, AIDS, myelodysplastic syndromes and other hematologic abnormalities, aplastic anemia, male pattern bladness, and bacterial, fungal, protozoan and viral infections, among others, and diagnostic assays for such conditions.

What is claimed is: 
     
       1. An isolated polynucleotide comprising a nucleotide sequence encoding a first polypeptide that has at least 97% identity over its entire length compared to the human HMVAB41 polypeptide as set forth in SEQ ID NO:2, or the complement of said nucleotide sequence, wherein % identity is equal to 100 (1-100n/103), wherein n is the total number of amino acids in the first polypeptide that are substituted, deleted or inserted compared to the polypeptide set forth as SEQ ID NO:2. 
     
     
       2. The isolated polynucleotide of claim 1, wherein said nucleotide sequence consists of the region of the polynucleotide as set forth in SEQ ID NO:1 that codes for the polypeptide as set forth in SEQ ID NO:2. 
     
     
       3. The isolated polynucleotide of claim 2, wherein said nucleotide sequence consists of the polynucleotide as set forth in SEQ ID NO:1. 
     
     
       4. The isolated polynucleotide of claim 1 which is DNA or RNA. 
     
     
       5. An expression vector comprising the isolated polynucleotide of claim 1 operably linked to a transcription promoter. 
     
     
       6. An isolated host cell comprising the vector of claim 5. 
     
     
       7. A process for producing an isolated host cell comprising the expression vector of claim 5, said process comprising either transforming or transfecting an isolated, compatible host cell with the expression vector of claim 5. 
     
     
       8. The isolated polynucleotide of claim 1 comprising a nucleotide sequence that codes for the human HMVAB41 polypeptide as set forth in SEQ ID NO:2. 
     
     
       9. An expression vector comprising the isolated polynucleotide of claim 8 operably linked to a transcription promoter. 
     
     
       10. An isolated host cell comprising the vector of claim 9. 
     
     
       11. A process for producing an isolated host cell that expresses human HMVAB41 polypeptide, said process comprising either transforming or transfecting an isolated, compatible host cell with the expression vector of claim 9. 
     
     
       12. A method for producing human HMVAB41 polypeptide comprising culturing the isolated host cell of claim 10 under conditions suitable for expression of the polynucleotide and production of said polypeptide, and then recovering the human HMVAB41 polypeptide from the culture.