Formulation containing a carrier, active ingredient, and surfactant for treating skin disorders

Abstract

One or more formulations for treating psoriasis and other skin disorders characterized by redness, itching, flaking, scaling, and plaque-type growth. The formulation includes a carrier component, one or more active ingredient components, and a surfactant component. The carrier preferably includes an alcohol in substantially equal volume with isopropyl myristate. The active ingredient component preferably includes a superpotent or high-potency corticosteroid such as clobetasol propionate, an anti-flaking ingredient such as zinc pyrithione, or a combination of the two. It may also include an anti-fungal compound. The surfactant component preferably includes an alkyl sulfate such as sodium lauryl sulfate. The formulations made by applied topically either in spray form or as a direct-contact liquid.

I claim: 
     
       1. A formulation for treating skin disorders consisting essentially of: a. about 0.01% to about 2% by weight of an active ingredient compound selected from the group consisting of clobetasol propionate, augmented betamethasone diproprionate, diflorasone diacetate, betamethasone valerate, betamethasone diproprionate, diflucortolone valerate, fluticasone valerate, hydrocortisone 17-butyrate, mometasone furoate, halobetasol propionate, desoximetasone, flucinonide, zinc pyrithione, coal tar, salicylic acid, selenium sulfide, and sulfur;   b. 0.1% to about 2% by weight of an anionic surfactant compound selected from the group consisting of soap, alkyl aryl sulphonate, alkyl ether sulfate, alkyl sulfate, and alcohol sulfate;   c. 0.3% to about 10% by weight of undecylenic acid; and   d. a carrier compound to make up the balance of weight of said formulation, said carrier compound formed of a combination of two components in a volume ratio of about 50/50, wherein a first carrier component of said combination of two components is selected from the group consisting essentially of ethyl alcohol and isopropyl alcohol and a second carrier component of said combination of two components is selected from the group consisting essentially of isopropyl myristate, isopropyl palmitate, octyl palmitate, octyl isononanoate, and isocetyl stearate.   
     
     
       2. The formulation as claimed in claim 1 wherein said first carrier component is ethyl alcohol and said second carrier component is isopropyl myristate. 
     
     
       3. The formulation as claimed in claim 1 wherein said first carrier component is isopropyl alcohol and said second carrier component is isopropyl myristate. 
     
     
       4. The formulation as claimed in claim 1 wherein said active ingredient compound is about 0.05% by weight of clobetasol propionate and about 0.25% by weight of zinc pyrithione. 
     
     
       5. The formulation as claimed in claim 4 wherein said anionic surfactant compound is about 0.1% by weight of sodium lauryl sulfate, the formulation including about 0.3% by weight of undecylenic acid. 
     
     
       6. The formulation as claimed in claim 1 wherein said anionic surfactant compound is about 0.1% by weight of sodium lauryl sulfate, the formulation including about 0.3% by weight of undecylenic acid. 
     
     
       7. The formulation as claimed in claim 6 wherein said active ingredient compound is about 0.05% by weight of clobetasol propionate and about 0.25% by weight of zinc pyrithione. 
     
     
       8. A formulation for treating skin disorders consisting essentially of: a. about 0.01% to about 0.10% by weight of clobetasol propionate;   b. 0.1% to about 2% by weight of an anionic surfactant compound selected from the group consisting of soap, alkyl aryl sulphonate, alkyl ether sulfate, alkyl sulfate, and alcohol sulfate;   c. 0.3% to about 10% by weight of undecylenic acid; and   d. a carrier compound to make up the balance of weight of said formulation, said carrier compound formed of a combination of two components in a volume ratio of about 50/50, wherein a first carrier component of said combination of two components is selected from the group consisting essentially of ethyl alcohol and isopropyl alcohol and a second carrier component of said combination of two components is isopropyl myristate.   
     
     
       9. The formulation as claimed in claim 8 consisting of about 0.05% by weight of clobetasol propionate. 
     
     
       10. The formulation as claimed in claim 8 wherein said anionic surfactant compound is about 0.1% by weight of sodium lauryl sulfate. 
     
     
       11. The formulation as claimed in claim 10 including about 0.3% by weight of undecylenic acid. 
     
     
       12. The formulation as claimed in claim 8 wherein said first carrier component is ethyl alcohol. 
     
     
       13. The formulation as claimed in claim 8 wherein said first carrier component is isopropyl alcohol. 
     
     
       14. A formulation for treating skin disorders consisting essentially of: a. about 0.01% to about 2% by weight of zinc pyrithione;   b. 0.1% to about 12% by weight of an anionic surfactant compound selected from the group consisting of soap, alkyl aryl sulphonate, alkyl ether sulfate, alkyl sulfate, and alcohol sulfate;   c. 0.3% to about 10% by weight of undecylenic acid; and   d. a carrier compound to make up the balance of weight of said formulation, said carrier compound formed of a combination of two components in a volume ratio of about 50/50, wherein a first carrier component of said combination of two components is selected from the group consisting essentially of ethyl alcohol and isopropyl alcohol and a second carrier component of said combination of two components is isopropyl myristate.   
     
     
       15. The formulation as claimed in claim 14 consisting of about 0.25% by weight of zinc pyrithione. 
     
     
       16. The formulation as claimed in claim 14 wherein said anionic surfactant compound is about 0.1% by weight of sodium lauryl sulfate. 
     
     
       17. The formulation as claimed in claim 16 including about 0.3% by weight of undecylenic acid. 
     
     
       18. The formulation as claimed in claim 14 wherein said first carrier component is ethyl alcohol. 
     
     
       19. The formulation as claimed in claim 14 wherein said first carrier component is isopropyl alcohol. 
     
     
       20. The formulation as claimed in claim 14 further comprising about 0.05% by weight of clobetasol propionate.