Muscarinic receptor agonists

Abstract

A compound of Formula (I): ##STR1## wherein R is a linkage independently selected from (CH 2 ) 12 or (CH 2 ) 4 O 3 ; and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.

What is claimed is: 
     
       1. A compound of Formula (I): ##STR6## wherein R is (CH 2 ) 12  or an acid addition salt or hydrate thereof. 
     
     
       2. The compound of claim 1 which is 1,12-bis-[3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazo-4-yloxy]-dodecane. 
     
     
       3. A pharmaceutical composition, comprising a therapeutically effective amount of a compound according to claim 1, and a pharmaceutically acceptable carrier. 
     
     
       4. A pharmaceutical composition, comprising a therapeutically effective amount of a compound according to claim 2, and a pharmaceutically acceptable carrier.