Human immune system associated molecules

Abstract

The invention provides human immune system associated proteins (HISAP) and polynucleotides which identify and encode HISAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HISAP.

What is claimed is: 
     
       1. An isolated and purified polynucleotide encoding a polypeptide selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8. SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, and SEQ ID NO:13. 
     
     
       2. An isolated and purified polynucleotide comprising a sequence which is completely complementary to the polynucleotide sequence of claim 1. 
     
     
       3. An isolated and purified polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:21, SEQ ID NO:22, SEQ ID NO:23, SEQ ID NO:24, SEQ ID NO:25, and SEQ ID NO:26. 
     
     
       4. An isolated and purified polynucleotide comprising a sequence which is completely complementary to the polynucleotide sequence of claim 3. SEQ ID NO:26. 
     
     
       5. An expression vector containing the polynucleotide of claim 1. 
     
     
       6. A host cell containing the expression vector of claim 5. 
     
     
       7. A method for producing a polypeptide, the method comprising the steps of: a) culturing the host cell of claim 6 under conditions suitable for the expression of the polypeptide; and   b) recovering the polypeptide from the host cell culture.   
     
     
       8. A method for detecting a polynucleotide, the method comprising the steps of: (a) hybridizing the polynucleotide of claim 2 to at least one of the nucleic acids in a sample, thereby forming a hybridization complex; and   (b) detecting the hybridization complex, wherein the presence of the hybridization complex correlates with the presence of the polynucleotide in the sample.   
     
     
       9. The method of claim 8 wherein the nucleic acids of the biological sample are amplified by the polymerase chain reaction prior to the hybridization step. 
     
     
       10. An isolated and purified fragment of the polynucleotide of claim 3 selected from the group consisting of nucleotide 402 to nucleotide 443 of SEQ ID NO:14, nucleotide 432 to nucleotide 467 of SEQ ID NO:17, nucleotide 418 to nucleotide 453 of SEQ ID NO:18, nucleotide 346 to nucleotide 366 of SEQ ID NO:19, nucleotide 278 to nucleotide 298 of SEQ ID NO:20, nucleotide 251 to nucleotide 283 of SEQ ID NO:21, nucleotide 358 to nucleotide 387 of SEQ ID NO:23, nucleotide 396 to nucleotide 419 of SEQ ID NO:24, nucleotide 163 to nucleotide 225 of SEQ ID NO:25, and nucleotide 389 to nucleotide 412 of SEQ ID NO:26. 
     
     
       11. An isolated and purified polynucleotide comprising a sequence which is completely complementary to the polynucleotide of claim 10. 
     
     
       12. A method for detecting a polynucleotide, the method comprising the steps of: (a) hybridizing the polynucleotide of claim 11 to at least one nucleic acid in a sample, thereby forming a hybridization complex; and   (b) detecting the hybridization complex, wherein the presence of the hybridization complex correlates with the presence of the polynucleotide in the sample.   
     
     
       13. The method of claim 12 further comprising amplifying the polynucleotide prior to hybridization. 
     
     
       14. An isolated and purified fragment of a polynucleotide selected from the group consisting of nucleotide 124 to nucleotide 150 of SEQ ID NO:15 and nucleotide 102 to nucleotide 128 of SEQ ID NO:16. 
     
     
       15. An isolated and purified fragment of a polynucleotide consisting of a sequence which is completely complementary to the polynucleotide of claim 14. 
     
     
       16. A method for detecting a polynucleotide, the method comprising the steps of: (a) hybridizing the polynucleotide of claim 15 to at least one nucleic acid in a sample, thereby forming a hybridization complex; and   (b) detecting the hybridization complex, wherein the presence of the hybridization complex correlates with the presence of the polynucleotide in the sample.   
     
     
       17. The method of claim 16 further comprising amplifying the polynucleotide prior to hybridization.