Diaryl substituted thiazoles useful in the treatment of fungal infections

Abstract

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

What is claimed is: 
     
       1. A compound of the formula: ##STR33## wherein R 16  is hydrogen, halo, nitro, lower alkoxy, cyano, trifluoromethyl or lower alkyl; R 17  is hydrogen, nitro, halo or cyano; and   R 18  and R 19  are the same or different and represent lower alkyl and lower alkenyl.   
     
     
       2. 2-(4'-nitrophenyl)-4-[4"-(N-methyl-N-allylaminomethyl)phenyl]-thiazole. 
     
     
       3. 2-(3'-nitrophenyl)-4-[4"-(N-methyl-N-allylaminomethyl)phenyl]thiazole. 
     
     
       4. 2-(4'-methoxy-3-nitrophenyl)-4-[4"-(dimethylaminomethyl) phenyl]thiazole. 
     
     
       5. 2-(4'-methoxy-3-nitrophenyl)-4-[4"-N-methyl-N-allylaminomthyl)phenyl]thiazole. 
     
     
       6. A pharmaceutical composition comprising an effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier. 
     
     
       7. A method for treating a fungal infection which comprises administering to a mammalian host an effective amount of a compound of claim 1 in unit dosage form.