Tubby 2 polypeptides

Abstract

Tubby 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Tubby 2 polypeptides and polynucleotides in the design of protocols for the treatment of diabetes, obesity, and atherosclerosis, among others, and diagnostic assays for such conditions.

What is claimed is:  
     
       1. An isolated polypeptide comprising an amino acid sequence which has at least 70% identity to the amino acid sequence of SEQ ID NO:2 over the entire length of SEQ ID NO:2, said identity being calculated using FASTA wherein the two sequences are aligned so that highest order match is obtained. 
     
     
       2. An isolated polypeptide as claimed in claim  1  in which the amino acid sequence has at least 80% identity, said identity being calculated using FASTA wherein the two sequences are aligned so that highest order match is obtained. 
     
     
       3. An isolated polypeptide as claimed in claim  1  in which the amino acid sequence has at least 90% identity, said identity being calculated using FASTA wherein the two sequences are aligned so that highest order match is obtained. 
     
     
       4. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2. 
     
     
       5. The isolated polypeptide of claim  4  consisting essentially of the amino acid sequence of SEQ ID NO:2. 
     
     
       6. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:4. 
     
     
       7. The polypeptide of claim  6  consisting essentially of the amino acid sequence of SEQ ID NO:4. 
     
     
       8. An isolated polypeptide comprising at least 50 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO:2. 
     
     
       9. The isolated polypeptide of claim  8  comprising at least 100 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO:2. 
     
     
       10. The isolated polypeptide of claim  8  comprising at least 200 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO:2. 
     
     
       11. The isolated polypeptide of claim  8  comprising at least 300 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO:2. 
     
     
       12. An isolated polypeptide comprising at least 50 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO:4. 
     
     
       13. The isolated polypeptide of claim  12  comprising at least 100 contiguous amino apids from the amino acid sequence set forth in SEQ ID NO:4. 
     
     
       14. The isolated polypeptide of claim  12  comprising at least 200 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO:4.