US6210944B1ExpiredUtility

Phosphoribosyl transferase from Staphylococcus aureus

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Assignee: SMITHKLINE BEECHAM CORPPriority: Aug 5, 1997Filed: Jul 29, 1999Granted: Apr 3, 2001
Est. expiryAug 5, 2017(expired)· nominal 20-yr term from priority
Inventors:Martin Karl Russel BurnhamMichael Arthur LonettoPatrick Vernon Warren
A61P 43/00A61P 27/02A61P 31/00A61P 27/00A61P 27/16A61P 25/00A61P 31/04A61P 13/00A61P 19/00A61K 38/00A61P 19/02C12N 9/1077A61P 13/02A61P 11/00A61P 17/00A61P 13/12A61P 1/00A61K 39/00
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PatentIndex Score
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Cited by
2
References
10
Claims

Abstract

The invention provides phosphoribosyl transferase polypeptides also called adenine phosphoribosyl transferases, from Staphylococcus aureus and DNA (RNA) encoding such phosphoribosyl transferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phosphoribosyl transferase polypeptides to screen for antibacterial compounds.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
       1. An isolated phosphoribosyl transferase polypeptide comprising SEQ ID NO:2. 
     
     
       2. A composition comprising the isolated polypeptide of claim  1  and a carrier. 
     
     
       3. The isolated polypeptide of claim  1 , wherein the isolated polypeptide comprises a heterologous amino acid sequence fused to SEQ ID NO:2. 
     
     
       4. A composition comprising the isolated polypeptide of claim  3  and a carrier. 
     
     
       5. The isolated polypeptide of claim  1 , wherein the isolated polypeptide consists of SEQ ID NO:2. 
     
     
       6. A composition comprising the isolated polypeptide of claim  5  and a carrier. 
     
     
       7. An isolated polypeptide comprising at least 50 consecutive amino acids of SEQ ID NO:2. 
     
     
       8. The isolated polypeptide of claim  7 , wherein the isolated polypeptide comprises a heterologous amino acid sequence fused to the at least 50 consecutive amino acids of SEQ ID NO:2. 
     
     
       9. An isolated polypeptide comprising at least 30 consecutive amino acids of SEQ ID NO:2. 
     
     
       10. The isolated polypeptide of claim  9 , wherein the isolated polypeptide comprises a heterologous amino acid sequence fused to the at least 30 consecutive amino acids of SEQ ID NO:2.

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