Avian extracellular calcium-sensing receptor

Abstract

The present invention is directed to an avian calcium-sensing receptor and to DNA sequences which encode the receptor. In addition, the invention is directed to methods and compositions which serve to modulate the serum concentration of calcium in humans and animals.

What is claimed is:  
     
       1. A polynucleotide consisting of a nucleotide sequence encoding the protein of SEQ ID NO:2. 
     
     
       2. A nucleic acid comprising the polynucleotide of claim  1 . 
     
     
       3. The nucleic acid of claim  2 , wherein said polynucleotide is operably linked to a promoter active in avian cells. 
     
     
       4. A host cell transformed with the nucleic acid of claim  3 . 
     
     
       5. The polynucleotide of claim  1 , wherein said polynucleotide has a nucleotide sequence consisting of that of SEQ ID NO:1. 
     
     
       6. A nucleic acid comprising the polynucleotide of claim  5 . 
     
     
       7. The nucleic acid of claim  6 , wherein said polynucleotide is operably linked to a promoter active in avian cells. 
     
     
       8. A host cell transformed with the nucleic acid of claim  7 . 
     
     
       9. A DNA construct comprising the polynucleotide of claim  1 , but wherein one or more nucleotides of codon 127 have been replaced by a different nucleotide. 
     
     
       10. The DNA construct of claim  9 , wherein said polynucleotide is operably linked to a promoter active in avian cells.