US6270757B1ExpiredUtility

Formulations for IL-11

75
Assignee: GENETICS INSTPriority: Apr 21, 1994Filed: Apr 21, 1994Granted: Aug 7, 2001
Est. expiryApr 21, 2014(expired)· nominal 20-yr term from priority
Inventors:Nicholas W. Warne
A61K 38/2073A61P 43/00A61P 7/00A61P 37/04
75
PatentIndex Score
42
Cited by
22
References
20
Claims

Abstract

The present invention provides novel formulations comprising IL-11 and glycine. Also provided are compositions, both liquid and lyophilized, comprising IL-11 and glycine and optionally, a buffering agent such as histidine and phosphate.

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
       1. A composition comprising IL-11 and glycine. 
     
     
       2. The composition of claim  1 , where the amount of said glycine ranges from 50 to 600 mM. 
     
     
       3. The composition of claim  1 , where the amount of said glycine is about 300 mM. 
     
     
       4. The composition of claim  1 , where the amount of said glycine is about 150 mM. 
     
     
       5. The composition of claim  1 , where the amount of said IL-11 is about 0.1 to 20 mg/mL. 
     
     
       6. The composition of claim  1 , where the amount of said IL-11 is about 5.0 mg/mL. 
     
     
       7. The composition of claim  1 , where the amount of said IL-11 is about 5.0 mg/mL and said glycine is about 300 mM. 
     
     
       8. A composition comprising IL-11, glycine, and a buffering agent. 
     
     
       9. The composition of claim  8 , where said buffering agent is a member selected from the group consisting of histidine and phosphate. 
     
     
       10. The composition of claim  9 , where said buffering agent is sodium phosphate. 
     
     
       11. The composition of claim  9 , where the amount of said phosphate ranges from about 5 mM to 20 mM. 
     
     
       12. The composition of claim  10 , where the amount of said phosphate is about 10 mM. 
     
     
       13. The composition of claim  9 , where the amount of said histidine ranges from about 5 mM to 40 mM. 
     
     
       14. The composition of claim  11 , where the amount of said histidine is about 20 mM. 
     
     
       15. A composition comprising about 5.0 mg/mL IL-11, 300 mM glycine, and 10 mM sodium phosphate. 
     
     
       16. A composition comprising about 5.0 mg/mL IL-11, 300 mM glycine, and 20 mM histidine. 
     
     
       17. A composition comprising des-Pro-IL-11 and glycine. 
     
     
       18. The composition of claim  17  where the amount of said des-Pro-IL-11 is about 0.1 to 20 mg/mL. 
     
     
       19. The composition of claim  17  where the amount of said glycine is about 50 to 600 mM. 
     
     
       20. A composition comprising about 5.0 mg/mL des-Pro-IL-11 and 300 mM glycine.

Cited by (0)

No later patents cite this yet.

References (0)

No backward citations on record.