Methods and compositions for inducing autoimmunity in the treatment of cancers

Abstract

Disclosed are methods and compositions for the prevention and treatment of cancers using lipid-carrier protein conjugate compositions for generating lipid-specific immune responses in an animal. Also disclosed are methods for making phosphatidylserine conjugate compositions and their formulation for use in a variety of pharmaceutical applications including the detection and treatment of a variety of cancers and related conditions.

What is claimed is:  
     
       1. A method for inhibiting cancer cell growth or killing cancer cells comprising eliciting a lipid specific antibody response with an immunologically effective amount of a composition comprising a phosphatidylserine/polypeptide conjugate. 
     
     
       2. The method of claim  1 , wherein said cancer cell is a lymphoid, renal or bladder cancer cell. 
     
     
       3. The method of claim  1 , wherein said cancer cell is comprised within an animal. 
     
     
       4. The method of claim  3 , wherein said animal is a human. 
     
     
       5. The method of claim  1 , wherein said composition further comprises a pharmaceutical excipient. 
     
     
       6. The method of claim  5 , wherein said composition is administered to said human, parenterally, subcutaneously, or by direct injection into a tissue site. 
     
     
       7. The method of claim  1 , wherein said lipid specific antibody response is elicited with phosphotidylserine/polypeptide conjugate comprising a polypeptide selected from the group consisting of BSA, KLH, BGG, diphtheria toxin, and β2-glycoprotein I. 
     
     
       8. The method of claim  7 , wherein said polypeptide is β 2 -glycoprotein I. 
     
     
       9. The method of claim  3 , wherein said cancer cell is comprised within a tumor. 
     
     
       10. The method of claim  9 , wherein said tumor is within a human. 
     
     
       11. A method of generating a lipid specific antibody response, comprising administering to an animal a pharmaceutical composition comprising an immunologically effective amount of a phosphatidylserine/polypeptide conjugate composition. 
     
     
       12. The method of claim  11 , wherein said animal comprises a cancer cell. 
     
     
       13. The method of claim  12 , wherein said cancer cell is a lymphoid, renal or bladder cancer cell. 
     
     
       14. The method of claim  12 , wherein said cancer cell is comprised within a tumor. 
     
     
       15. The method of claim  11 , wherein said animal is a human. 
     
     
       16. The method of claim  15 , wherein said human has cancer. 
     
     
       17. The method of claim  16 , wherein said cancer is comprised within a tumor. 
     
     
       18. The method of claim  11 , wherein said animal is a mouse. 
     
     
       19. The method of claim  11 , wherein said animal is a rat, a hamster, a guinea pig or a goat. 
     
     
       20. The method of claim  11 , wherein said composition is administered to said animal parenterally, subcutaneously, or by direct injection into a tissue site. 
     
     
       21. The method of claim  11 , wherein said lipid specific antibody response is elicited with a phosphotidylserine/polypeptide conjugate comprising a polypeptide selected from the group consisting of BSA,KLH,BGG, diphtheria toxin,and β2-glycoprotein I. 
     
     
       22. The method of claim  21 , wherein said polypeptide is β2-glycoprotein I.