Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives

Abstract

A method of treating a mammal comprises administering to a mammal an effective amount to provide a desired therapeutic effect in the mammal of a compound selected from the group consisting of those having the formula:and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R1 and R2 each is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any of the 5-, 6-, 7- or 8-positions of the quinoxaline nucleus, and R3, R4 and R5 each is located in one of the remaining 5-, 6-, 7- or 8-positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide desired therapeutic effects, such as reduction in peripheral pain.

What is claims is:  
     
       1. A method of treating a mammal comprising administering to a mammal an effective amount to provide a desired therapeutic effect in said mammal of a compound selected from the group consisting of those having the formula                    
       and pharmaceutically acceptable acid addition salts thereof and mixtures thereof, wherein R 1  and R 2  each is independently selected from the group consisting of H, alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms, the 2-imidazolin-2-ylamino group may be in any of the 5-, 6-, 7- or 8-positions of the quinoxaline nucleus, and R 3 , R 4  and R 5  each is located in one of the remaining 5-, 6-, 7- and 8-positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals containing 1 to 3 carbon atoms, said desired therapeutic effect being reduction in chronic peripheral pain. 
     
     
       2. The method of claim  1  wherein the 2-imidazolin-2-ylamino group is in the 6-position of the quinoxaline nucleus, R 3  is in the 5-position of the quinoxaline nucleus and is selected from the group consisting of Cl, Br and alkyl radicals containing 1 to 3 carbon atoms, and R 4  and R 5  are both H. 
     
     
       3. The method of claim  2  wherein R 2  is a methyl radical. 
     
     
       4. The method of claim  3  wherein R 3  is Br. 
     
     
       5. The method of claim  2  wherein R 3  is Br. 
     
     
       6. The method of claim  1  wherein R 2  is a methyl radical. 
     
     
       7. The method of claim  1  wherein R 1  is H and R 2  is selected from the group consisting of alkyl radicals containing 1 to 4 carbon atoms and alkoxy radicals containing 1 to 4 carbon atoms. 
     
     
       8. The method of claim  1  wherein said formula is                    
     
     
       9. The method of claim  1  wherein R 3  is in the 5-position of the quinoxaline nucleus and is selected from the group consisting of H and alkyl radicals containing 1 to 3 carbon atoms. 
     
     
       10. The method of claim  9  wherein the 2-imidazolin-2-ylamino group is in the 6- position of the quinoxaline nucleus, and R 4  and R 5  are both H. 
     
     
       11. The method of claim  10  wherein both R 3  is selected from the group consisting of H and methyl radical. 
     
     
       12. The method of claim  9  wherein both R 1  and R 2  are H. 
     
     
       13. The method of claim  12  wherein R 3  is selected from the group consisting of H and methyl radical. 
     
     
       14. The method of claim  9  wherein R 3  is selected from the group consisting of H and methyl radical. 
     
     
       15. The method of claim  1  wherein both R 1  and R 2  are H. 
     
     
       16. The method of claim  1  wherein said formula is:                    
     
     
       17. The method of claim  1  wherein said formula is: