Aryloxyaniline derivatives

Abstract

An aryloxyaniline derivative represented by the formula:wherein Ar1 and Ar2 are each a substituted or unsubstituted phenyl group, pyridyl group or naphthyl group, R1 is a hydrogen atom, an alkyl group, etc., X1 is a hydrogen atom, an alkyl group, etc., y1 is a branched or unbranched alkylene group having 1 to 6 carbon atoms or a single bond; or a pharmaceutically acceptable salt thereof can provide medicines having a high affinity for MDR, and therefore, exhibiting a therapeutic or preventive effect on anxiety, related diseases thereto, depression, etc.

What is claimed is:  
     
       1. An aryloxyaniline derivative represented by the formula:                    
       wherein Ar 1  and Ar 2  are the same or different, and are each a substituted or unsubstituted phenyl group or a naphthyl group, R 1  is a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, an alkoxy group having 1 to 10 carbon atoms, a substituted or unsubstituted phenyl group or a group of the formula: 
       —NR 2 (R 3 ) (wherein R 2  and R 3  are the same or different, and are each a hydrogen atom or an alkyl group having 1 to 10 carbon atoms), X 1  is a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a phenoxy group, a halogen atom, a trifluoromethyl group or a carbamoyl group, Y 1  is a branched or unbranched alkylene group having 1 to 6 carbon atoms or a single bond; or a pharmaceutically acceptable salt thereof, and the substituted phenyl group is a phenyl group substituted with one to three members selected from the group consisting of an alkyl group having 1 to 10 carbon atoms, an alkyl group having 1 to 10 carbon atoms substituted with halogen atoms; hydroxyl groups; carboxyl groups or alkoxycarbonyl groups, an alkenyl group having 2 to 10 carbon atoms, an alkoxy group having 1 to 10 carbon atoms, an alkylthio group having 1 to 10 carbon atoms, a group of the formula: —O—Z—R 4  (wherein Z is a branched or unbranched alkylene group having 1 to 10 carbon atoms, and R 4  is an amino group, an amino group substituted with one or two of an alkyl group having 1 to 7 carbon atoms, a cyclic amino group having 2 to 7 carbon atoms, a hydroxyl group, a carboxyl group or an alkoxycarbonyl group), an alkanoyl group having 2 to 10 carbon atoms or a ketal form thereof, a formyl group or an acetal form thereof, a carboxyl group, an alkoxycarbonyl group having 2 to 10 carbon atoms, a carbamoyl group, a carbamoyl group substituted with one or two of an alkyl group having 1 to 10 carbon atoms on the nitrogen atom, an aminosulfonyl group, an aminosulfonyl group substituted with one or two of an alkyl group having 1 to 10 carbon atoms on the nitrogen atom, a halogen atom and a nitro group.  
     
     
       2. A medicine comprising the aryloxyaniline derivative or the pharmaceutically acceptable salt thereof according to claim  1 . 
     
     
       3. A ligand for MDR comprising the aryloxyaniline derivative or the pharmaceutically acceptable salt thereof according to claim  1  as an active ingredient.