US6335361B1ExpiredUtility

Method of treating benign forgetfulness

94
Assignee: JUVENON INCPriority: Nov 3, 1999Filed: Nov 2, 2000Granted: Jan 1, 2002
Est. expiryNov 3, 2019(expired)· nominal 20-yr term from priority
Inventors:Nathan Hamilton
A61P 43/00A61K 45/06A61K 31/198A61K 31/385A61K 31/205A61P 25/28A61K 31/221A61K 31/122
94
PatentIndex Score
86
Cited by
81
References
36
Claims

Abstract

Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the oxidant is thioctic acid. Preferably 0.12 grams to 3 grams of carnitine (particularly ALC) and 0.12 and 1.5 grams of R-α-lipoic acid are administered. Optionally, coenzyme Q and/or creatine also are administered. Preferably 10 mg to 500 mg/day of coenzyme Q10 and 1 to 30 grams/day of creatine are administered. The same method can be used to treat cognition deficits associated with carbon monoxide poisoning, mild traumatic brain injury, Type 2 diabetes mellitus, obsessive-compulsive disorder, environmental toxin exposure, and other conditions.

Claims

exact text as granted — not AI-modified
We claim:  
     
       1. A method of treating age-related memory deficits, the method comprising administering effective amounts of a suitable antioxidant, a carnitine and optionally coenzyme Q and/or creatine. 
     
     
       2. The method of  claim 1  wherein the carnitine administered is ALC and the effective amount is about 0.025 grams/day to about 3 grams/day. 
     
     
       3. The method of  claim 1  wherein the antioxidant administered is R-α-lipoic acid. 
     
     
       4. The method of  claim 1  wherein the antioxidant is administered in the amount of about 0.025 grams/day to about 1.5 grams/day. 
     
     
       5. The method of  claim 1  wherein the coenzyme Q is coenzyme Q10 and is administered in the amount of about 10 mg/day to about 500 mg/day. 
     
     
       6. The method of  claim 1  wherein the creatine is administered in the amount of about 1 gram/day to about 30 grams/day. 
     
     
       7. A method of treating Mild Traumatic Brain Injury, the method comprising administering effective amounts of a suitable antioxidant, a carnitine and optionally coenzyme Q and/or creatine. 
     
     
       8. The method of  claim 7  wherein the carnitine administered is ALC and the effective amount is about 0.025 grams/day to about 3 grams/day. 
     
     
       9. The method of  claim 7  wherein the antioxidant administered is R-α-lipoic acid. 
     
     
       10. The method of  claim 7  wherein the antioxidant is administered in the amount of about 0.025 grams/day to about 1.5 grams/day. 
     
     
       11. The method of  claim 7  wherein the coenzyme Q is coenzyme Q10 and is administered in the amount of about 10 mg/day to about 500 mg/day. 
     
     
       12. The method of  claim 7  wherein the creatine is administered in the amount of about 1 gram/day to about 30 grams/day. 
     
     
       13. A method of treating Carbon Monoxide poisoning, the method comprising administering effective amounts of a suitable antioxidant, a carnitine and optionally coenzyme Q and/or creatine. 
     
     
       14. The method of  claim 9  wherein the carnitine administered is ALC and the effective amount is about 0.025 grams/day to about 3 grams/day. 
     
     
       15. The method of  claim 13  wherein the antioxidant administered is R-α-lipoic acid. 
     
     
       16. The method of  claim 13  wherein the antioxidant is administered in the amount of about 0.025 grams/day to about 1.5 grams/day. 
     
     
       17. The method of  claim 13  wherein the coenzyme Q is coenzyme Q10 and is administered in the amount of about 10 mg/day to about 500 mg/day. 
     
     
       18. The method of  claim 13  wherein the creatine is administered in the amount of about 1 gram/day to about 30 grams/day. 
     
     
       19. A method of treating memory deficits associated with Type 2 Diabetes Mellitus (DM), the method comprising administering effective amounts of a suitable antioxidant, a carnitine and optionally coenzyme Q and/or creatine. 
     
     
       20. The method of  claim 19  wherein the carnitine administered is ALC and the effective amount is about 0.025 grams/day to about 3 grams/day. 
     
     
       21. The method of  claim 19  wherein the antioxidant administered is R-α-lipoic acid. 
     
     
       22. The method of  claim 19  wherein the antioxidant is administered in the amount of about 0.025 grams/day to about 1.5 grams/day. 
     
     
       23. The method of  claim 19  wherein the coenzyme Q is coenzyme Q10 and is administered in the amount of about 10 mg/day to about 500 mg/day. 
     
     
       24. The method of  claim 19  wherein the creatine is administered in the amount of about 1 gram/day to about 30 grams/day. 
     
     
       25. A method of treating memory deficits associated with Obsessive-Compulsive Disorder, the method comprising administering effective amounts of a suitable antioxidant, a carnitine and optionally coenzyme Q and/or creatine. 
     
     
       26. The method of  claim 25  wherein the carnitine administered is ALC and the effective amount is about 0.025 grams/day to about 3 grams/day. 
     
     
       27. The method of  claim 26  wherein the antioxidant administered is R-α-lipoic acid. 
     
     
       28. The method of  claim 26  wherein the antioxidant is administered in the amount of about 0.025 grams/day to about 1.5 grams/day. 
     
     
       29. The method of  claim 13  wherein the coenzyme Q is coenzyme Q10 and is administered in the amount of about 10 mg/day to about 500 mg/day. 
     
     
       30. The method of  claim 13  wherein the creatine is administered in the amount of about 1 gram/day to about 30 grams/day. 
     
     
       31. A method of treating memory deficits associated with Environmental Toxin Exposure, the method comprising administering effective amounts of a suitable antioxidant, a carnitine and optionally coenzyme Q and/or creatine. 
     
     
       32. The method of  claim 31  wherein the carnitine administered is ALC and the effective amount is about 0.025 grams/day to about 3 grams/day. 
     
     
       33. The method of  claim 31  wherein the antioxidant administered is R-α-lipoic acid. 
     
     
       34. The method of  claim 31  wherein the antioxidant is administered in the amount of about 0.025 grams/day to about 1.5 grams/day. 
     
     
       35. The method of  claim 31  wherein the coenzyme Q is coenzyme Q10 and is administered in the amount of about 10 mg/day to about 500 mg/day. 
     
     
       36. The method of  claim 31  wherein the creatine is administered in the amount of about 1 gram/day to about 30 grams/day.

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