Bioactive glass treatment of inflammation in skin conditions

Abstract

This invention relates to a method for treating inflammatory symptoms such as burning, redness, itching, swelling and pain which accompany skin disorders other than wounds of the skin. The method comprising topical application of a topical medicinal composition comprising a non-interlinked, particulate bioactive glass mixed with a topical medicinal carrier to the site of the skin disorder.

What is claimed is:  
     
       1. A method of treating inflammatory symptoms related to skin disorders, other than wounds and burns, in a mammal, comprising topically applying to the site of the inflammatory skin disorder an inflammation treating amount of non-interlinked, particulate bioactive glass having a particle size range less than about 90 microns, the bioactive glass having the following compositional weight percentages: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                                                     SiO 2   
                   40-86  
                 
                     
                   CaO 
                   10-46  
                 
                     
                   Na 2 O 
                   0-35 
                 
                     
                   P 2 O 5   
                   2-15 
                 
                     
                   CaF 2   
                   0-25 
                 
                     
                   B 2 O 3   
                   0-10 
                 
                     
                   K 2 O 
                   0-8  
                 
                     
                   MgO 
                   0-5.  
                 
                     
                     
                 
             
                
               
               
                
                
                
                
                
                
                
                
                
               
            
           
         
       
     
     
       2. The method of  claim 1 , further comprising applying along with the bioactive glass, topical creams, ointments, gels, or lotions. 
     
     
       3. The method of  claim 1 , further comprising applying along with the bioactive glass, one or more additional therapeutic agents. 
     
     
       4. The method of  claim 3  wherein one or more therapeutic agents are selected from the group consisting of healing promotion agents, anti-inflammatory agents, antiseptic agents, and topical anesthetic agents. 
     
     
       5. The method of  claim 1 , wherein the composition of the bioactive glass has the following compositional weight percentages: 
       
         
           
                 
                 
                 
               
                     
                     
                 
                     
                   Compound 
                   Percent 
                 
                     
                     
                 
                     
                 
                 
                 
                 
               
                     
                   SiO 2   
                   45 
                 
                     
                   CaO 
                   24.5 
                 
                     
                   Na 2 O 
                   24.5 
                 
                     
                   P 2 O 5   
                   6. 
                 
                     
                     
                 
             
                
                
                
               
               
                
               
            
             
                
                
                
                
                
               
            
           
         
       
     
     
       6. The method of  claim 1 , wherein the bioactive glass has a particle size range less than about 20 microns. 
     
     
       7. The method of  claim 1 , wherein the bioactive glass has a particle size range less than about 2 microns.