Wound healing compositions

Abstract

Methods and compositions based on chemical analogs of angiotensin II and analogs of angiotensin II fragments useful for accelerating wound healing in mammals.

What is claimed is:  
     
       1. A peptide with an amino acid sequence consisting a sequence selected of the general formula: 
       R1-Arg-norLeu-R2-R3-His-Pro-R4,  
       wherein R1 is selected from the group consisting of H and Asp;  
       R2 is selected from the group consisting of Tyr, Tyr(PO3)2, and homoSer;  
       R3 is selected from the group consisting of Ile and norLeu; and  
       R4 is selected from the group consisting of H, Phe, and Ile.  
     
     
       2. The peptide of  claim 1  selected from the group consisting of SEQ ID NO:5, SEQ ID NO:9, and SEQ ID NO:15. 
     
     
       3. The peptide of  claim 1  wherein R1 is Asp. 
     
     
       4. The peptide of  claim 3  selected from the group consisting of SEQ ID NO:5 and SEQ ID NO:15. 
     
     
       5. The peptide of  claim 3  wherein R5 is H. 
     
     
       6. The peptide of  claim 5 , wherein the peptide is SEQ ID NO:15. 
     
     
       7. A pharmaceutical composition comprising: 
       (a) an amount effective for accelerating wound healing of a peptide of  claim 1 ; and  
       (b) a pharmaceutically acceptable carrier.  
     
     
       8. A pharmaceutical composition comprising: 
       (a) an amount effective for accelerating wound healing of a peptide of  claim 2 ; and  
       (b) a pharmaceutically acceptable carrier.  
     
     
       9. A pharmaceutical composition comprising: 
       (a) an amount effective for accelerating wound healing of a peptide of claim  3 ; and  
       (b) a pharmaceutically acceptable carrier.  
     
     
       10. A pharmaceutical composition comprising: 
       (a) an amount effective for accelerating wound healing of a peptide of  claim 4 ; and  
       (b) a pharmaceutically acceptable carrier.  
     
     
       11. A pharmaceutical composition comprising: 
       (a) an amount effective for accelerating wound healing of a peptide of  claim 5 ; and  
       (b) a pharmaceutically acceptable carrier.  
     
     
       12. A pharmaceutical composition comprising: 
       (a) an amount effective for accelerating wound healing of a peptide of  claim 6 ; and  
       (b) a pharmaceutically acceptable carrier.  
     
     
       13. A method for accelerating wound healing, comprising applying to a wound an amount effective to accelerate wound healing of a peptide according to  claim 1 . 
     
     
       14. The method of  claim 13 , wherein the method is used to treat a wound selected from the group consisting of bums, surgical incisions, lacerations, ulcers, and traumas.