Prostaglandin agonists and their use to treat bone disorders

Abstract

This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.

What is claimed is:  
     
       1. The compound (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid, or a pharmaceutically acceptable salt thereof. 
     
     
       2. The compound (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid sodium salt. 
     
     
       3. A method for treating a vertebrate having a condition which presents with low bone mass comprising administering to said vertebrate a therapeutically effective amount of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid, or a pharmaceutically acceptable salt thereof. 
     
     
       4. The method of  claim 3  wherein osteoporosis, osteotomy, childhood idiopathic bone loss or bone loss associated with periodontitis is treated. 
     
     
       5. The method of  claim 4  wherein osteoporosis is treated in a human. 
     
     
       6. The method of  claim 5  wherein glucocorticoid-induced osteoporosis, hyperthyroidism-induced osteoporosis, immobilization-induced osteoporosis, heparin-induced osteoporosis or immunosuppressive-induced osteoporosis is treated. 
     
     
       7. A method for augmenting and maintaining bone mass in a vertebrate comprising administering to said vertebrate a therapeutically effective amount of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid, or a pharmaceutically acceptable salt thereof. 
     
     
       8. The method of  claim 7  wherein bone healing following facial reconstruction, maxillary reconstruction or mandibular reconstruction is treated, vertebral synostosis is induced or long bone extension is enhanced, the healing rate of a bone graft is enhanced or prosthetic ingrowth is enhanced. 
     
     
       9. The method of  claim 7  wherein a bone fracture is treated in a human. 
     
     
       10. A pharmaceutical composition which comprises an amount of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. 
     
     
       11. A method for treating glaucoma in a mammal suffering from glaucoma comprising administering to said mammal a therapeutically effective amount of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid, or a pharmaceutically acceptable salt thereof. 
     
     
       12. A method for treating ocular hypertension in a mammal suffering from ocular hypertension comprising administering to said mammal a therapeutically effectivew amount of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)-phenoxy)-acetic acid, or a pharmaceutically acceptable salt thereof.