Germinal center kinase cell cycle proteins

Abstract

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

We claim:  
     
       1. An isolated TNIK protein, comprising an amino acid sequence selected from the group consisting of the full length amino acid sequences set forth in SEQ ID NOs:9-15. 
     
     
       2. An isolated TNIK protein, comprising an amino acid sequence encoded by a nucleotide sequence selected from the group consisting of the full length nucleotide sequences set forth in SEQ ID NOs:2-8. 
     
     
       3. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:9. 
     
     
       4. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:10. 
     
     
       5. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:11. 
     
     
       6. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:12. 
     
     
       7. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:13. 
     
     
       8. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:14. 
     
     
       9. The isolated TNIK protein according to  claim 1 , comprising the full length amino acid sequence set forth in SEQ ID NO:15. 
     
     
       10. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:2. 
     
     
       11. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:3. 
     
     
       12. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:4. 
     
     
       13. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:5. 
     
     
       14. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:6. 
     
     
       15. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:7. 
     
     
       16. The isolated TNIK protein according to  claim 2 , comprising an amino acid sequence encoded by the full length nucleotide sequence set forth in SEQ ID NO:8.