Use of polyamino acid derivatives as preserving agents, compositions comprising them and preserving process using them

Abstract

Processes for preserving compositions, such as cosmetic and dermatological compositions, which may be intended for topical applications, through the use of at least one certain polyamino acid derivatives. Cosmetic and pharmaceutical compositions comprising at least one certain polyamino acid derivatives

What is claimed is:  
     
       1. A process for preserving a composition comprising: 
       introducing into said composition at least one preserving agent chosen from polyamino acid derivatives of formula (I) and salts thereof,                    
       in which: 
       X is chosen from O, S, NH and NR″, wherein R″ is chosen from saturated and unsaturated, linear and branched C 1-6  hydrocarbon-based radicals;  
       R 1  is chosen from:  
       (i) linear and branched, saturated and unsaturated C 1-40  hydrocarbon-based radicals;  
       (ii) radicals of the formula                    
        wherein s is a number chosen from 0, 1, 2, 3 and 4; and R 4  is chosen from hydrogen and radicals chosen from —NH 2 , —OH, —SH, —CHOHCH 3 , —CONH 2 , —NH—C(NH 2 )═NH, —C 6 H 5 , —C 6 H 4 OH and                    
       (iii) radicals of the formula                    
        wherein m is a number chosen from 3, 4 and 5;  
       R 2  is chosen from hydrogen; saturated and unsaturated, linear and branched C 1-8  hydrocarbon-based radicals; and radicals chosen from —CH 2 C 6 H 5 , —CH 2 C 6 H 4 OH, —CH 2 OH, —CHOHCH 3 , —(CH 2 ) t —NH 2 , wherein t is a number chosen from 3 and 5;  
       R 3  is chosen from hydrogen and saturated and unsaturated, linear and branched C 1-6  hydrocarbon-based radicals; and  
       n is a number greater than 1 chosen such that the number average molecular weight of the polyamino acid derivative ranges from 100 to 200 000;  
       wherein the repeating unit may be identical or different for the same derivative.  
     
     
       2. A process according to  claim 1 , wherein said at least one preserving agent is chosen from an antimicrobial agent. 
     
     
       3. A process according to  claim 2 , wherein said antimicrobial agent is chosen from an antibacterial agent, an antiviral agent, an anti-yeast agent and an antifungal agent. 
     
     
       4. A process according to  claim 1 , wherein R 1  is chosen from linear and branched, saturated and unsaturated C 1-40  hydrocarbon-based radicals substituted with at least one hydroxyl radical, at least one radical —NRR′, or at least one hydroxyl radical and at least one radical —NRR′, wherein R and R′, which may be identical or different, are chosen from hydrogen and saturated and unsaturated, linear and branched C 1-6  hydrocarbon-based radicals. 
     
     
       5. A process according to  claim 1 , wherein R 1  is chosen from linear and branched, saturated and unsaturated C 1-40  hydrocarbon-based radicals interrupted with at least one hetero atom chosen from N, O and Si. 
     
     
       6. A process according to  claim 1 , wherein in said polyamino acid derivatives of formula (I) and salts thereof, at least one of the following definitions apply: 
       R 1  is chosen from linear and branched, saturated and unsaturated C 8-40  hydrocarbon-based radicals;  
       R 2  is hydrogen;  
       R 3  is chosen from saturated, linear and branched C 1-6  hydrocarbon-based radicals; and  
       n is chosen from a number ranging from 2 to 100 and a number chosen such that the number average molecular weight of said polyamino acid derivative ranges from 150 to 10,000.  
     
     
       7. A process according to  claim 6 , wherein R 3  is chosen from methyl and ethyl radicals. 
     
     
       8. A process according to  claim 6 , wherein R 1  is chosen from linear and branched, saturated and unsaturated C 8-40  hydrocarbon-based radicals substituted with at least one hydroxyl radical, at least one radical —NRR′, or at least one hydroxyl radical and at least one radical —NRR′, wherein R and R′, which may be identical or different, are chosen from hydrogen and saturated and unsaturated, linear and branched C 1-6  hydrocarbon-based radicals. 
     
     
       9. A process according to  claim 6 , wherein R 1  is chosen from linear and branched, saturated and unsaturated C 8-40  hydrocarbon-based radicals interrupted with at least one hetero atom chosen from N, O and Si. 
     
     
       10. A process according to  claim 6 , wherein 
       R 1  is chosen from linear and branched, saturated and unsaturated C 8-40  hydrocarbon-based radicals;  
       R 2  is hydrogen;  
       R 3  is chosen from saturated, linear and branched C 1-6  hydrocarbon-based radicals; and  
       n is chosen from a number ranging from 2 to 100 and a number chosen such that the number average molecular weight of said polyamino acid derivative ranges from 150 to 10,000.  
     
     
       11. A process according to  claim 1 , wherein in said polyamino acid derivatives of formula (I) and salts thereof, at least one of the following definitions apply: 
       X is chosen from O, S and NH;  
       R 1  is chosen from linear and branched, saturated C 10-24  hydrocarbon-based radicals; and linear and branched unsaturated hydrocarbon-based radicals;  
       R 2  is hydrogen;  
       R 3  is a methyl radical; and  
       n is chosen from a number ranging from 4 to 50 and a number chosen such that the number average molecular weight of said polyamino acid derivative ranges from 300 to 8,000.  
     
     
       12. A process according to  claim 11 , wherein X is NH. 
     
     
       13. A process according to  claim 11 , wherein R 1  is chosen from linear and branched, saturated C 10-24  hydrocarbon-based radicals substituted with at least one hydroxyl radical. 
     
     
       14. A process according to  claim 13 , wherein said linear and branched, saturated C 10-24  hydrocarbon-based radicals are substituted with 1, 2, 3, or 4 hydroxyl radicals. 
     
     
       15. A process according to  claim 11 , wherein R 1  is chosen from linear and branched unsaturated hydrocarbon-based radicals substituted with at least one hydroxyl radical. 
     
     
       16. A process according to  claim 1  further comprising a physiologically acceptable medium. 
     
     
       17. A process according to  claim 1 , wherein said preserving agent is present in said composition in an amount ranging from 0.001% to 30% by weight, relative to the total weight of the composition. 
     
     
       18. A process according to  claim 17 , wherein said preserving agent is present in said composition in an amount ranging from 0.01% to 15% by weight, relative to the total weight of the composition. 
     
     
       19. A process according to  claim 18 , wherein said preserving agent is present in said composition in an amount ranging from 0.5% to 5% by weight, relative to the total weight of the composition. 
     
     
       20. A process according to  claim 1 , wherein said composition is chosen from a cosmetic composition and a pharmaceutical composition. 
     
     
       21. A process according to  claim 6 , wherein said composition is chosen from a cosmetic composition and a pharmaceutical composition. 
     
     
       22. A process according to  claim 11 , wherein said composition is chosen from a cosmetic composition and a pharmaceutical composition. 
     
     
       23. A process according to  claim 1 , wherein said composition is in the form of a make-up product applied to at least one area of the body chosen from the skin of the face, the skin of the body, and the lips. 
     
     
       24. A process according to  claim 23 , wherein said makeup product is chosen from a foundation, a face powder, an eye shadow, a concealer stick, a cover stick, an eyeliner, a mascara, a lipstick, a nail varnish and a nailcare product. 
     
     
       25. A process according to  claim 1 , wherein said composition is in the form of a dermatological or cosmetic care product for the skin of the face, the skin of the body, or the lips. 
     
     
       26. A process according to  claim 25 , wherein said composition is in the form of a dermatological or cosmetic care product for the skin of the scalp. 
     
     
       27. A process according to  claim 25 , wherein said dermatological or cosmetic care product is chosen from a lipcare base, a fixing base to be applied over a conventional lipstick, an antisun composition, an artificial tanning composition, a deodorant product, a care composition for the face, a matte-effect composition for the face, a cleansing gel, a cleansing cream, a make-up-removing gel, a make-up-removing cream, a protective body milk, a bodycare milk, and a purifying milk. 
     
     
       28. A process according to  claim 27 , wherein said care composition for the face is chosen from a day product and a night product. 
     
     
       29. A process according to  claim 27 , wherein said care composition for the face is an anti-wrinkle product. 
     
     
       30. A process according to  claim 1 , wherein the form of said composition is chosen form a deodorant composition, an aftershave gel, an aftershave lotion, and a hair-removing cream. 
     
     
       31. A process according to  claim 1 , wherein said composition is in the form of a pharmaceutical composition. 
     
     
       32. A process according to  claim 1 , wherein said composition is in the form of a solid. 
     
     
       33. A process according to  claim 32 , wherein said solid is chosen from a cleansing soap and a cleansing bar. 
     
     
       34. A process according to  claim 1 , wherein said composition is in the form of an aerosol comprising a propellant under pressure. 
     
     
       35. A process according to  claim 1 , wherein said composition is in the form of a haircare composition. 
     
     
       36. A process of  claim 30 , wherein said haircare composition is chosen from a shampoo, a hairsetting lotion, a medicated lotion, a styling cream, a styling gel, a dye composition, a restructuring lotion for the hair, a permanent-waving composition, a lotion for preventing hair loss, a gel for preventing hair loss, an antiparasitic shampoo; an antidandruff lotion, an antidandruff shampoo; and a medicated shampoo. 
     
     
       37. A process according to  claim 36 , wherein said dye composition is an oxidation dye composition. 
     
     
       38. A process according to  claim 36 , wherein said dye composition is a coloring shampoo. 
     
     
       39. A process according to  claim 36 , wherein said medicated shampoo is an anti-seborrhoeic shampoo. 
     
     
       40. A process according to  claim 1 , wherein said composition is in the form of a buccodental composition. 
     
     
       41. A process according to  claim 40 , wherein said buccodental composition is a toothpaste.