Acid addition salts of hydropyridine derivatives

Abstract

Acid addition salts of 2-acetoxy-5-(alpha-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]-pyridine. The acid addition salts of tetrahydrothienopyridine derivatives of the present invention exhibit excellent oral absorption, metabolization into the active compound, and platelet aggregation-inhibiting effects, low toxicity, and excellent storage and handling stabilities, and are useful as medicaments, preferably preventive or therapeutic agents (particularly therapeutic agents) for diseases caused by a thrombus or an embolus, still more preferably preventive or therapeutic agents (particularly therapeutic agents) for thrombosis or embolism.

What is claimed is:  
     
       1. 2-Acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride. 
     
     
       2. 2-Acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine maleate. 
     
     
       3. A medicament composition comprising a pharmaceutically effective amount of the salt according to  claim 1  as an active ingredient in combination with a pharmaceutically acceptable carrier. 
     
     
       4. A medicament composition comprising a pharmaceutically effective amount of the salt according to  claim 2  as an active ingredient in combination with a pharmaceutically acceptable carrier. 
     
     
       5. The medicament composition according to  claim 3 , wherein said medicament is for prevention or treatment of a thrombus formation-induced or an embolization-induced disease in a warm blooded animal. 
     
     
       6. The medicament composition according to  claim 4 , wherein said medicament is for prevention or treatment of a thrombosis or an embolism in a human. 
     
     
       7. The medicament composition according to  claim 6 , wherein said medicament is for treatment of a thrombosis or an embolism in a human. 
     
     
       8. A method for prevention or treatment of a thrombus formation-induced or an embolization-induced disease in a warm blooded animal which comprises administering an effective amount of the salt according to  claim 1 . 
     
     
       9. The method according to  claim 8 , wherein the warm blooded animal is a human. 
     
     
       10. The method according to  claim 9 , wherein the method is for treatment of a thrombosis. 
     
     
       11. The method according to  claim 9 , wherein the method is for treatment of an embolism. 
     
     
       12. A method for prevention or treatment of a thrombus formation-induced or an embolization-induced disease in a warm blooded animal which comprises administering an effective amount of the salt according to  claim 2 . 
     
     
       13. The method according to  claim 12 , wherein the warm blooded animal is a human. 
     
     
       14. The method according to  claim 13 , wherein the method is for treatment of a thrombosis. 
     
     
       15. The method according to  claim 13 , wherein the method is for treatment of an embolism.