Method of screening substances with a glycidyl methacrylate covered styrene-glycidyl methacrylate polymer

Abstract

A compound possessing physiological activity is coupled to a styrene-glycidyl methacrylate polymer through a spacer. Compounds that may be used include receptors such as proteins, and 3-[(5-(2,3-dimethoxy-6-methyl-benzoquinonyl)]-2-nonyl-2-propionic a preferred spacer is an ethylene glycol diglycidyl ether derivative. Preferably, the whole surface of the styrene-glycidyl methacrylate polymer in microsphere form is covered with glycidyl methacrylate. The microsphere may be used for isolating and detecting substances such as proteins that bind to the coupled compound.

What is claimed is:  
     
       1. A process of screening for a substance which binds to a substance possessing physiological activity, wherein the substance possessing physiological activity is bound through a spacer to a styrene-glycidyl methacrylate polymer, wherein essentially the entire surface of the styrene-glycidyl methacrylate polymer is covered with glycidyl-methacrylate.