Compounds for the treatment of ischemia

Abstract

A3 agonists, methods of using such A3 agonists and pharmaceutical compositions containing such A3 agonists. The A3 agonists are useful for the reduction of tissue damage resulting from tissue ischemia or hypoxia.

What is claimed is:  
     
       1. A compound having the formula CV                    
       wherein R 3  is halo, trifluoromethyl, cyano, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkoxy, ethenyl or ethynyl. 
     
     
       2. The compound as recited in  claim 1  wherein R 3  is trifluoromethyl. 
     
     
       3. The compound as recited in  claim 1  wherein R 3  is fluoro. 
     
     
       4. The compound as recited in  claim 1  wherein R 3  is chloro. 
     
     
       5. A compound having the Formula CVI                    
       wherein R 2  is H, (C 1 -C 3 )alkyl or (C 3 -C 5 )cycloalkyl; and R 3  is halo, trifluoromethyl, cyano, (C 1 -C 3 )alkyl, (C 1 -C 3 )alkyloxy, ethenyl or ethynyl. 
     
     
       6. The compound as recited in  claim 5  wherein R 2  is H; and R 3  is chloro. 
     
     
       7. The compound as recited in  claim 5  wherein R 2  is H; and R 3  is fluoro. 
     
     
       8. The compound as recited in  claim 5  wherein R 2  is cyclopropyl; and R 3  is fluoro.