US6831175B2ExpiredUtilityA1
Kinase inhibitors
Est. expiryDec 13, 2021(expired)· nominal 20-yr term from priority
Inventors:Qun LiKeith W. WoodsGui-Dong ZhuJohn P. FischerJianchun GongTongmei LiVirajkumar B. GandhiSheela A. ThomasGarrick PackardXiaohong SongJason AbramsRobert Bruce DieboldJurgen DingesCharles W. HutchinsVincent S. StollSaul H. RosenbergVincent L. Giranda
C07D 401/14C07D 403/14C07D 471/04C07D 213/63C07D 409/14C07D 401/12C07D 475/02C07D 401/04
97
PatentIndex Score
214
Cited by
64
References
21
Claims
Abstract
Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. A compound of formula (I)
or a therapeutically acceptable salt thereof, wherein
X is selected from the group consisting of C(R 8 ) and N; wherein R 8 is selected from the group consisting of hydrogen, alkyl, amino, carboxy, cyano, halo, hydroxy, and amido;
X′ is selected from the group consisting of C and N;
Y is C;
Y′ is C(R 9 ); wherein R 9 is selected from the group consisting of hydrogen and -L 2 -L 3 (R 3 )(R 6 );
Z is C;
provided that X or X′ is N, and provided that both X and X′ are not N;
L 1 is selected from the group consisting of a bond, —O—, —NR 5 —, alkenyl, alkynyl, —C(O)—, —S—, —S(O)—, —S(O) 2 —, —S(O) 2 N(R 5 )—, —N(R 5 )S(O) 2 —, —C(R 12 ) 2 —, —C(R 12 ) 2 N(R 5 )—, —N(R 5 )C(O)—, and —C(O)N(R 5 )—; wherein each group is drawn with its left end attached to R 1 and its right end attached to the aromatic ring;
L 2 is selected from the group consisting of a bond, —O—, —C(R 12 ) 2 —, —S—, —N(R 5 )—, —N(R 5 )C(O)—, and —C(O)N(R 5 )—;
L 3 is selected from the group consisting of a bond, alkylidene and alkylene, wherein the alkylidene and the alkylene are optionally substituted with one or two substituents independently selected from the group consisting of alkoxy, amino, cyano, and hydroxy, with the proviso that if L 2 is a bond, —O—, or —S— then L 3 is not a bond;
R 1 is selected from the group consisting of monocyclic or bicyclic aryl, heteroaryl, and heterocycle;
R 2 and R 4 are independently absent or selected from the group consisting of hydrogen, alkenyl, alkyl, alkynyl, amino, aryl, arylalkynyl, cyano, cyanoalkenyl, halo, heteroaryl, heterocycle, hydroxyalkyl, and nitro; or
R 2 and L 1 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; or
R 4 and L 2 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; provided that when L 3 is alkylidene, R 4 and L 2 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle;
R 3 is absent or selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, arylalkylamino, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle;
R 6 is selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, arylalkylamino, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle;
provided that when L 1 and L 2 are bonds, at least one of R 3 and R 6 other than hydrogen;
R 5 is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, arylcarbonyl, arylsulfonyl, and heteroarylsulfonyl;
R 7 is absent or selected from the group consisting of hydrogen, alkyl, cyanoalkenyl, and -L 2 -L 3 (R 3 )(R 6 ); or
R 7 and L 1 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of aryl, heteroaryl, and heterocycle; and
each R 12 is selected from the group consisting of hydrogen, alkenyl, alkyl, alkynyl, amino, aryl, cyano, halo, heteroaryl, heterocycle, and nitro.
2. A compound of formula (II)
or a therapeutically acceptable salt thereof, wherein
L 1 is selected from the group consisting of a bond, —O—, —N(R 5 )—, alkenyl, alkynyl, —N(R 5 )C(O)—, and —C(O)N(R 5 )—;
L 2 is selected from the group consisting of a bond, —O—, —N(R 5 )—, —N(R 5 )C(O)—, and —C(O)N(R 5 )—;
L 3 is selected from the group consisting of a bond, alkylidene, and alkylene, wherein the alkylidene and the alkylene are optionally substituted with one or two substituents independently selected from the group consisting of amino, cyano, and hydroxy, with the proviso that if L 2 is a bond, —O—, or —S— then L 3 is not a bond;
R 1 is selected from the group consisting of monocyclic or bicyclic aryl, heteroaryl, and heterocycle;
R 2 and R 4 are independently selected from the group consisting of hydrogen, alkenyl, alkynyl, arylalkynyl, amino, cyano, cyanoalkenyl, halo, hydroxyalkyl, and heteroaryl; wherein the heteroaryl is selected from the group consisting of furyl, pyrazinyl, thiazolyl, and thienyl; or
R 2 and L 1 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of dihydropyrrolyl, pyrazolyl, and phenyl; or
R 4 and L 2 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of dihydropyrrolyl, phenyl, pyridinyl, and pyrrolyl; wherein the ring can be optionally substituted with oxo;
provided that when L 3 is alkylidene, R 4 and L 2 , together with the carbon atoms to which they are attached, form a ring selected from the group consisting of dihydropyrrolyl, phenyl, pyridinyl, and pyrrolyl; wherein the ring can be optionally substituted with oxo;
R 3 is absent or selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle;
R 6 are independently selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, arylalkylthio, aryloxy, arylthio, cycloalkyl, heteroaryl, heteroarylalkoxy, heteroaryloxy, and heterocycle;
provided that when L 1 and L 2 are bonds, at least one of R 3 and R 6 is other than hydrogen;
R 5 is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, arylcarbonyl, arylsulfonyl, and heteroarylsulfonyl; and
X is N.
3. A compound of formula (III)
or a therapeutically acceptable salt thereof, wherein
L 1 is selected from the group consisting of a bond, —O—, —N(R 5 )—, alkenyl, alkynyl, and —N(R 5 )C(O)—;
L 2 is selected from the group consisting of a bond, —O—, —N(R 5 )—, —N(R 5 )C(O)—, and —C(O)N(R 5 )—;
L 3 is alkylene, wherein the alkylene is substituted with one or two substituents independently selected from the group consisting of amino and hydroxy;
R 1 is selected from the group consisting of monocyclic or bicyclic aryl, heteroaryl, and heterocycle;
R 2 and R 4 are independently selected from the group consisting of hydrogen and halo;
R 3 and R 6 are independently selected from the group consisting of hydrogen, monocyclic or bicyclic aryl, arylalkoxy, and heteroaryl; provided that when L 1 and L 2 are bonds, at least one of R 3 and R 6 is other than hydrogen; and
R 5 is selected from the group consisting of hydrogen and alkyl.
4. The compound according to claim 1 or claim 2 wherein L 1 is alkenyl.
5. The compound according to claim 4 wherein Y′ is C(R 9 ) wherein R 9 is -L 2 -L 3 (R 3 )(R 6 ) and wherein L 2 is —O—.
6. The compound according to claim 5 selected from the group consisting of N,N-dimethyl—N-[2-({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)ethyl]amine;
(1S)-2-(1H-indol-3-yl)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine;
(1R)-2-(1H-indol-3-yl)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine;
1-(1H-indol-3-yl)-3-({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)propan-2-ol;
(1S)-2-(1-benzothien-3-yl)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine;
(1S)-2,2-diphenyl-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine;
(1S)-1-{4-[(2,6-dichlorobenzyl)oxy]benzyl}-2-({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)ethylamine;
(1S)-2-(benzyloxy)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine;
N,N-dimethyl-N-[(1S,2S)-1-methyl-2-phenyl-2-({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)ethyl]amine;
(1S)-2-(2-naphthyl)-1-[({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine;
(1S)-2-({2-chloro-5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)-1-(1H-indol-3-ylmethyl)ethylamine;
(1S)-2-({6-chloro-5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)-1-(1H-indol-3-ylmethyl)ethylamine;
(1S)-2-(1H-indol-3-yl)-1-[({5-[(Z)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)methyl]ethylamine; and
N-[(2E)-3-(4-bromophenyl)prop-2-enyl]-N-[2-({5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}oxy)ethyl]amine.
7. The compound according to claim 4 wherein Y′ is C(R 9 ) wherein R 9 is -L 2 -L 3 (R 3 )(R 6 ) and wherein L 2 is selected from the group consisting of a bond, —N(R 5 )—, —N(R 5 )C(O)—, and —C(O)N(R 5 )—.
8. The compound according to claim 7 selected from the group consisting of
N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-N-{5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}amine;
(2S)-2-amino-4-phenyl-N-{5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}butanamide;
N-(aminomethyl)-5-[(E)-2-pyridin-4-ylvinyl]nicotinamide; and
(1R)-3-{6-chloro-5-[(E)-2-pyridin-4-ylvinyl]pyridin-3-yl}-1-(1H-indol-3-ylmethyl)propylamine.
9. The compound according to claim 1 or claim 2 wherein L 1 is a bond.
10. The compound according to claim 9 wherein Y′ is C(R 9 ) wherein R 9 is -L 2 -L 3 (R 3 )(R 6 ) and wherein L 2 is —O—.
11. The compound according to claim 10 selected from the group consisting of
4-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)benzonitrile;
(1S)-2-(1H-indol-3-yl)-1-{[(5-isoquinolin-6-ylpyridin-3-yl)oxy]methyl}ethylamine;
(1R)-2-(1H-indol-3-yl)-1-{[(5-quinolin-6-ylpyridin-3-yl)oxy]methyl}ethylamine;
(1S)-2-[(6-chloro-5-isoquinolin-6-ylpyridin-3-yl)oxy]-1-(1H-indol-3-ylmethyl)ethylamine;
(1S)-2-[(2-chloro-5-isoquinolin-6-ylpyridin-3-yl)oxy]-1-(1H-indol-3-ylmethyl)ethylamine;
5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)-1H-isoindole-1,3(2H)-dione;
5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)isoindolin-1-one;
(1S)-2-[(5-cinnolin-6-ylpyridin-3-yl)oxy]-1-(1H-indol-3-ylmethyl)ethylamine;
(1S)-2-{[5-(1H-indazol-5-yl)pyridin-3-yl]oxy}-1-(1H-indol-3-ylmethyl)ethylamine;
5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)-1,3-dihydro-2H-indol-2-one;
(1S)-2-{[5-(2,1,3-benzoxadiazol-5-yl)pyridin-3-yl]oxy}-1-(1H-indol-3-ylmethyl)ethylamine;
(1S)-2-(1H-indol-3-yl)-1-{[(5-thieno[2,3-c]pyridin-2-ylpyridin-3-yl)oxy]methyl}ethylamine;
(3Z)-5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; and
6-(5-{[(2R)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)-1,3-benzothiazol-2(3H)-one.
12. The compound according to claim 9 wherein Y′ is C(R 9 ) wherein R 9 is -L 2 -L 3 (R 3 )(R 6 ) and wherein L 2 is selected from the group consisting of a bond, —N(R 5 )C(O)—, and —N(R 5 )—.
13. The compound according to claim 12 selected from the group consisting of
(2S)-2-amino-3-(1H-indol-3-yl)-N-[5-(1,6-naphthyridin-2-yl)pyridin-3-yl]propanamide;
N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-N-[5-(1,6-naphthyridin-2-yl)pyridin-3-yl]amine;
(1R)-1-(1H-indol-3-ylmethyl)-3-(5-isoquinolin-6-ylpyridin-3-yl)propylamine;
2-(1H-indol-3-yl)-2-(5-isoquinolin-6-ylpyridin-3-yl)ethanamine; and
2-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)propan-1-amine.
14. The compound according to claim 9 wherein Y′ is C(R 9 ) wherein R 9 is -L 2 -L 3 (R 3 )(R 6 ) and wherein L 2 and R 4 , together with the atoms to which they are attached, form a heterocycle ring.
15. The compound according to claim 14 which is
(3Z)-3-[(2S)-2-amino-3-(1H-indol-3-yl)propylidene]-5-isoquinolin-6-yl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one.
16. The compound according to claim 1 or claim 2 wherein L 1 is selected from the group consisting of alkynyl, —N(R 5 )C(O)—, —N(R 5 )—, and —O—.
17. The compound according to claim 16 selected from the group consisting of
(1S)-2-(1H-indol-3-yl)-1-({[5-pyridin-4-ylethynyl)pyridin-3-yl]oxy}methyl)ethylamine;
5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}-N-pyridin-4-ylnicotinamide;
N 4 -(3-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}phenyl)pyrimidine-2,4-diamine;
N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-N′-isoquinolin-5-ylpyridine-3,5-diamine; and
N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-N-[5-(isoquinolin-5-yloxy)pyridin-3-yl]amine.
18. The compound according to claim 1 or claim 2 wherein L 1 and R 2 , together with the atoms to which they are attached, form an aryl ring.
19. The compound according to claim 18 which is
(1S)-2-(1H-indol-3-yl)-1-{[(6-pyridin-4-ylquinolin-3-yl)oxy]methyl}ethylamine.
20. The compound according to claim 1 or claim 2 selected from the group consisting of
3-Butoxyl-5-[2-(4-pyridinyl)vinyl]pyridine;
3-Methoxyl-5-[2-(4-pyridinyl)vinyl]pyridine;
S-3-[2-Amino-3-phenyl-propyloxyl]-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride;
3-[2-(1H-3-Indolyl)-ethoxyl]-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride;
3-[2-(1H-3-Indolyl)-propyloxyl]-5-[2-(4-pyridinyl)vinyl]pyridine;
S-3-[2-Amino-3-(4-benzyloxylphenyl)-propyloxyl]-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride;
R-3-{2-Amino-3-benzyloxypropyloxyl}-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride;
3-(1-Methyl-imidazole-4-methoxyl)-5-[2-(4-pyridinyl)vinyl]pyridine;
S-3-{2-Amino-3-[3-hydroxylphenyl]-propyloxyl}-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
S-3-{2-Amino-3-[3-cyanophenyl]-propyloxyl}-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
3-[1-(4-Cyanobenzyl)-imidazole-4-methoxyl]-5-[2-(4-pyridinyl)vinyl]pyridine;
S-3-[2-Amino-3-(1-methyl-1H-3-indolyl)-propyloxyl]-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
S-3-[2-Dimethylamino-3-(1H-3-indolyl)-propyloxyl]-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
S-3-[2-Amino-3-(1-naphthyl)-propyloxyl]-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
3-(2-Aminoethoxyl)-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
3-(3-Aminopropyloxyl)-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
S-3-(2-Amino3-methylbutyloxyl)-5-[2-(4-pyridinyl)vinyl]pyridine hydrochloride salt;
3-(1-Methyl-3-piperidinyloxyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-(2-Chlorobenzyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-(N-Benzyl-N-methylaminoethoxyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-(6-(N,N-Dimathylamino)hexyloxyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-(2-Thiophenoxyl-ethoxyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-(1-Methyl-3-pyrrolidinyloxyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-[(1-Methyl-2-piperidinyl)methoxyl]-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
3-(1-Pyridinyl-ethoxyl)-5-[2-(4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
4-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-N-hydroxyl-benzamidine trifluoroacetic acid salt;
4-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-benzamidine trifluoroacetic acid salt;
3-[(2S)-2-Amino-3-(1H-3-indolyl)-propyloxyl]-6-(3-pyridinyl)-quinoline;
3-[(2S)-2-Amino-3-(1H-3-indolyl)-propyloxyl]-6-(3-quinolinyl)-quinoline;
3-[(2S)-2-Amino-3-(1H-3-indolyl)-propyloxyl]-5-[2-(2-amino-4-pyridinyl)vinyl]pyridine trifluoroacetic acid salt;
5-[(2S)-2-(Amino-3-(1H-3-indolyl)-propyloxyl]-3-[2-(2-amino-4-pyridinyl)vinyl]-2-chloro-pyridine trifluoroacetic acid salt;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-naphthalen-2-yl-pyridin-3-yloxy)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-isoquinolin-5-yl-pyridin-3-yloxy)-ethylamine;
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-2H-isoquinolin-1-one;
(1S)-2-[5-(3-Chloro-isoquinolin-6-yl)-pyridin-3-yloxyl]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-([3,4′]Bipyridinyl-5-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine trifluoroacetic acid;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(2-pyridin-2-yl-vinyl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-pyridin-3-ylethynyl-pyridin-3-yloxy)-ethylamine trifluoroacetic acid salt;
(1S)-2-[5-(2-Fluoro-pyridin-4-ylethynyl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine trifluoroacetic acid salt;
(1S)-4-{5-[2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-ylethynyl}-pyridin-2-ol trifluoroacetic acid salt;
(1S)-2-[6-Chloro-5-(1-chloro-isoquinolin-6-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine trifluoroacetic acid salt;
Bis-[3-(4-Bromo-phenyl)-allyl]-{2-[5-(2-pyridin-4-yl-vinyl)-pyridin-3-yloxy]-ethyl}-amine hydrochloride;
trans-[4-(2-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propylamino]-pyridin-3-yl}-vinyl)-pyrimidin-2-yl]-carbamic acid ethyl ester trifluoroacetic acid salt;
1-Amino-6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-isoquinoline trifluoroacetic acid salt;
6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1-chloro-isoquinoline trifluoroacetic acid salt;
(2S)-2-Amino-3-(1H-indol-3-yl)-N-[5-(2-pyridin-4-yl-vinyl)-pyridin-3-yl]-propionamide;
(2S)-2-Amino-3-(naphtha-1-yl)-N-[5-(2-pyridin-4-yl-vinyl)-pyridin-3-yl]-propionamide hydrochloride;
(2S)-2-Amino-3-phenyl-N-[5-(2-pyridin-4-yl-vinyl)-pyridin-3-yl]-propionamide hydrochloride;
S-2-Amino-3-(imidazol-4-yl)-N-[5-(2-pyridin-4-yl-vinyl)-pyridin-3-yl]-propionamide hydrochloride;
(1R)-2-(1H-indol-3-yl)-1-{[(5-isoquinolin-6-ylpyridin-3-yl)oxy]methyl}ethylamine;
(1S)-5-{5-[2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1H-indazol-3-ylamine;
(1S)-6-{5-[2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1H-indazol-3-ylamine;
2-Amino-N-[(1S)-1-(1H-indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethyl]-acetamide;
(2S)-2-Amino-N-[(1S)-1-(1H-indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethyl]-propionamide;
2-Dimethylamino-N-[(1S)-1-(1H-indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethyl]-acetamide;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[3-(1H-pyrrol-2-yl)-1H-indazol-5-yl]-pyridin-3-yloxy}-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-phenyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Cyclopropyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-[5-(3-Ethyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[3-(1-methyl-1H-imidazol-2-yl)-1H-indazol-5-yl]-pyridin-3-yloxy}-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-thiazol-2-yl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-{5-1H-(1H-Imidazol-2-yl)-1H-indazol-5-yl]-pyridin-3-yloxy}-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-thiophen-2-yl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-morpholin-4-yl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(1,3-Dimethyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[3-(3-methyl-1H-indazol-5-yl)-phenoxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[3-(4-methyl-piperazin-1-yl)-1H-indazol-5-yl)-pyridin-3-yloxy}-ethylamine;
(1S)-(5-{5-[2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1H-indazol-3-yl)-dimethyl-amine;
(1S)-(4-(5-(2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-benzyl)-phenyl-amine;
(1S)-(4-(5-(2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-methanol;
(1S)-2-(5-(4-Fluoro-phenyl)-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-4-(5-(2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-benzoic acid;
(1S)-2-(3-Bromo-5-isoquinolin-6-yl-phenoxyoxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
N4-(3-(5-(2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-pyrimidine-2,4-diamine;
(1S)-3-(2-Amino-3-(1H-indol-3-yl)-propoxy)-5-isoquinolin-6-yl-phenylamine;
((2S)-2-Amino-5-(5-(2-amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl-(3-chloro-phenyl-methanone;
(1S)-N6-(3-(5-(2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-9H-purine-2,6-diamine;
(3-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-pyrimidin-2yl-amine;
(3-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-thiazol-2yl-amine;
N-(3-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-acetamide;
6-(5-(4-(1H-Indol-3-ylmethyl)-piperazin-1-yl)-pyridin-3-yl)-isoquinoline;
3-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-5-isoquinolin-6-yl-benzoic acid;
4-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenylamine;
N-(4-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-acetamide;
N6-(4-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-9H-purine-2,6-diamine;
N4-(4-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-pyrimidine-2,4-diamine;
(4-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-phenyl)-pyrimidin-2-yl-amine;
3-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-5-isoquinolin-6-yl-benzonitrile;
5′-Benzyloxy-5-isoquinolin-6-yl-(3,3′)bipyridinyl;
(7-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-pyrido(2,3-d)pyrimidin-4-yl)-phenyl-amine;
(7-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-pyrido(2,3-d)pyrimidin-4-yl)-ethyl-amine;
(7-(5-((2S)-2-Amino-3-(1H-indol-3-yl)-propoxy)-pyridin-3-yl)-pyrido(2,3-d)pyrimidin-4-yl)-benzyl-amine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(6-isoquinolin-6-yl-pyridin-2-yloxy)-ethylamine;
(1S)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-1-phenyl-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(6-(3-methyl-1H-indazol-5-yl)-pyridin-2-yloxy)-ethylamine;
(1S)-1-Cyclohexylmethyl-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
(1S)-1-Benzyl-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-2-(5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-phenyl-ethylamine;
(1S)-2-(5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-phenyl-ethylamine;
4-((2S)-2-Amino-3-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)propyl)-benzonitrile;
(1S)-2-(5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-napthalen-2-ylmethyl-ethylamine;
4-((2S)-2-Amino-3-(5-isoquinolin-6-yl-pyridin-3-yloxy-propyl)-benzonitrile;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-napthalen-2-ylmethyl)-ethylamine;
(1S)-1-Benzyl-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
(1S)-1-(4-Fluoro-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-(4-Fluoro-benzyl)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
2-((2S)-2-Amino-3-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-propyl)-benzonitrile;
2-((2S)-2-Amino-3-(5-isoquinolin-6-yl)-pyridin-3-yloxy)-propyl)-benzonitrile;
(1S)-2-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-pyridin-4-ylmethyl-ethylamine;
(1S)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-1-pyridin-4-ylmethyl-ethylamine;
(1S)-1-(4-Methyl-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-(4-methyl-benzyl)-ethylamine;
(1S)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-quinolin-3-ylmethyl-ethylamine;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-quinolin-3-ylmethyl-ethylamine;
(1R)-1-Benzyl-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1R)-1-Benzyl-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
4-((2S)-2-Amino-3-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-propyl)-phenol;
(1S)-1-(4-Benzyloxy-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-(3-Methyl-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-(2-Methyl-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-(4-nitro-benzyl)-ethylamine;
(1S)-1-(4-Methoxy-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-Biphenyl-4-ylmethyl-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-2-(5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-napthalen-1-ylmethyl-ethylamine;
(1S)-1-(3-Chloro-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
3-((2S)-2-Amino-3-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-propyl)-benzonitrile;
(1S)-1-(3,4-Difluoro-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-(3,4-Dimethoxy-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-(3-Fluoro-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-1-(3-trifluoromethyl-benzyl)-ethylamine;
(1S)-1-(4-Ethoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-tert-Butyl-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
(1S)-1-(4-Methoxy-3-methyl-benzyl)-2-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-ethylamine;
2-((2S)-2-Amino-3-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy)-propyl)-4-methyl-phenol;
(1S)-1-Methyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(±)-1-(1H-Benzoimidazol-2-ylmethyl)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
(±)-1-(1H-Indazol-3-ylmethyl)-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
(1S)-1-(2-Fluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2-Chloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-thiophen-2-ylmethyl-ethylamine;
(1R)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
1-(4-Chloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(4-pyrrol-1-yl-benzyl)-ethylamine;
(1S)-1-(4-Methyl-benzylsulfanylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2-trifluoromethyl-benzyl])-ethylamine;
(1R)-1-Benzyl-3-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propylamine;
(1R)-1-Benzyl-4-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-butylamine;
(1S)-1-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-3-phenyl-propylamine;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-(1-methyl-1H-indol-3-ylmethyl)-ethylamine trifloroacetic acid salt;
(1S)-[1-(1H-Indol-3-ylmethyl)-2-(5-isoquinolin-6-y1-pyridin-3-yloxy)-ethyl]-dimethyl-amine;
(1S)-1-Benzo[b]thiophen-3-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-thiophen-3-ylmethyl-ethylamine;
(1S)-1-Benzyloxymethyl-2-(5-isoquinolin-6-yl-pyridin-3-yloxy)-ethylamine;
(1S)-1-Benzyloxymethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-(naphthalen-2-yloxymethyl)-ethylamine;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-(pyridin-3-yloxymethyl)-ethylamine;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-(quinolin-7-yloxymethyl)-ethylamine;
(2S)-4-[2-Amino-3-(5-isoquinolin-6-yl-pyridin-3-yloxy)-propoxy]-benzonitrile;
(2S)-N′-(5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl)-3-phenyl-propane-1,2-diamine;
(2S)-N-(2-Amino-3-phenyl-propyl)-N-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-methanesulfonamide;
(2S)-N-(2-Amino-3-phenyl-propyl)-N-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-benzenesulfonamide;
(2S)-N-(2-Amino-3-phenyl-propyl)-N-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-benzamide;
(2S)-N-(2-Amino-3-phenyl-propyl)-N-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-acetamide;
(2S)-3-[2-Amino-3-(1H-indol-3-yl)-propylidene]-5-isoquinolin-6-yl-1,3-dihydro-indol-2-one;
(1S)-2-(5-Isoquinolin-6-yl-pyridin-3-yloxy)-1-(1-methyl-1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(1H-pyrrolo[2,3-b]pyridin-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-{5-[2-(2-Fluoro-pyridin-4-yl)-vinyl]-pyridin-3-yloxy}-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[2-(2-methoxy-pyridin-4-yl)-vinyl]-pyridin-3-yloxy}-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[2-(2-phenoxy-pyridin-4-yl)-vinyl]-pyridin-3-yloxy}-ethylamine;
(1S)-2-{5-[2-(2-Benzylsulfanyl-pyridin-4-yl)-vinyl]-pyridin-3-yloxy}-1-(1H-indol-3-ylmethyl)-ethylamine;
[4-(2-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl }-vinyl)-pyridin-2-yl]-cyclopropyl-amine;
[4-(2-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-vinyl)-pyridin-2-yl]-benzyl-amine;
[4-(2-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl }-vinyl)-pyridin-2-yl]-ethyl-amine;
[4-(2-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-vinyl)-pyridin-2-yl]-methyl-amine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[2-(2-indol-1-yl-pyridin-4-yl)-vinyl]-pyridin-3-yloxy}-ethylamine;
(±)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2-methyl-1H-indol-3-ylmethyl)-ethylamine;
7-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl }-quinazolin-2-ylamine;
2-Phenyl-2-(3-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-6-yl)-ethylamine;
Naphthalen-2-yl-(3-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-6-yl)-acetonitrile;
2-Naphthalen-2-yl-2-(3-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-6-yl)-ethylamine;
(3-Isoquinolin-6-yl-1H-pyrazolo[3,4-b]pyridin-6-yl)-phenyl-acetonitrile;
2-(3-Isoquinolin-6-yl-1H-pyrazolo[3,4-b]pyridin-6-yl)-2-phenyl-ethylamine;
(1S)-1-Benzyl-2-(3-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-5-yloxy)-ethylamine;
2-Benzyl-3-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propylamine;
(1S)-1-(1H-idol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphthyridin-5-yloxy)-ethylamine;
(1R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphthyridin-5-yloxy)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-pyridin-3-ylsulfanyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-ylsulfanyl]-ethylamine;
(1S)-1-(4-Bromo-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(2-methyl-quinazolin-7-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(1H-indol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-{5-[4-(1H-tetrazol-5-yl)-phenyl]-pyridin-3-yloxy}-ethylamine;
(1S)-1-Benzyl-2-[3-(3-methyl-1H-indazol-5-yl)-phenoxy]-ethylamine;
(1S)-1-Benzyl-2-[6-(3-methyl-1H-indazol-5-yl)-pyridin-2-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(4-thiophen-3-yl-benzyl)-ethylamine;
(1S)-1-(4-Iodo-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
[4-((2S)-2-Amino-3-phenyl-propoxy)-2-(3-methyl-1H-indazol-5-yl)-phenyl]-methanol;
(1S)-2-[5-(1H-Benzotriazol-5-yl)-pyridin-3-yloxyl]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-[5-(1H-Benzotriazol-5-yl)-pyridin-3-yloxy]-1-benzyl-ethylamine;
(1S)-1-Benzyl-2-[5-(3-morpholin-4-yl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Benzyl-2-{5-[3-(4-methyl-piperazin-1-yl)-1H-indazol-5-yl]-pyridin-3-yloxy}-ethylamine;
(1S)-{5-[5-(2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-1H-indazol-3-yl}-dimethyl-amine;
(1S)-{5-[5-(2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-1H-indazol-3-yl}-(2-methoxy-ethyl)-amine;
{5-[5-((2S)-2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-1H-indazol-3-yl}-(2-morpholin-4-yl-ethyl)-amine;
5-[5-((2S)-2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-1H-indazol-3-ylamine;
N-{5-[5-((2S)-2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-1H-indazol-3-yl}-2,2,2-trifluoro-acetamide;
(2S)-2-Amino-N-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-3-phenyl-propionamide;
(1S)-2-[5-(3-Benzyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-Benzyl-2-[5-(3-benzyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Benzyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-methyl-ethylamine;
(6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-cinnolin-4-yl)-phenyl-amine;
(1S)-2-[5-(1H-Indazol-6-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-2,3-dihydro-isoindol-1-one;
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1H-cinnolin-4-one;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(4-phenyl-cinnolin-6-yl)-pyridin-3-yloxy]-ethylamine;
(6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-cinnolin-4-yl)-benzyl-amine;
(6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-cinnolin-4-yl)-methyl-amine;
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-cinnolin-4-ylamine;
[(3S)-3-(5-Isoquinolin-6-yl-pyridin-3-yloxymethyl)-1,2,3,4-tetrahydro-b-carboline-9-yl]-methanol;
3-(5-Isoquinolin-6-yl-pyridin-3-yloxymethyl)-2,3,4,9-tetrahydro-1H-□-carboline;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1H-indazole-3-carboxylic acid;
5-[5-((2S)-2-tert-Butoxycarbonylamino-3-hydroxy-propoxy)-pyridin-3-yl]-3-methyl-indazole-1-carboxylic acid tert-butyl ester;
5-[5-((2S)-Aziridin-2-ylmethoxy)-pyridin-3-yl]-3-methyl-1H-indazole;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(3-trifluoromethoxy-benzyl)-ethylamine;
(1S)-1-(3,5-Dichloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,3-Dichloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Biphenyl-3-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Chloro-4-fluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Chloro-3-fluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(4-trifluoromethoxy-benzyl)-ethylamine;
(1S)-1-(2-Fluoro-4-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Fluoro-5-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2-Methoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(3-{(2S)-2-Amino-3-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propyl}-phenyl)-dimethyl-amine;
(1S)-1-(4-Chloro-2-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Iodo-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxyl]-ethylamine;
(1S)-(1S)-1-(3-Fluoro-4-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Fluoro-4-methoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[6-Chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(3,4-dichloro-benzyl)-ethylamine;
(1S)-1-(2-Fluoro-6-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Fluoro-3-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Furan-2-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Benzofuran-2-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Fluoro-4-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Chloro-3-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Furan-3-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2-Fluoro-5-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Chloro-5-fluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(3,4,5-trifluoro-benzyl)-ethylamine;
(1S)-1-(4-Fluoro-3-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,4-Dichloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Chloro-3-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxyl]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2-trifluoromethoxy-benzyl)-ethylamine;
(1S)-1-(2,5-Dimethoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(4-methylsulfanyl-benzyl)-ethylamine;
(1S)-1-(2-Cyclohexyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,5-Dichloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,5-Dimethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,3-Dimethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3,4-Dichloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,4-Dimethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Fluoro-4-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3,5-Dimethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Biphenyl-2-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3,4-Dimethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,3-Difluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,5-Difluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,6-Dichloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,4-Difluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,6-Dimethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3,5-Difluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2,6-Difluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Benzo[1,3]dioxol-5-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Fluoro-3-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2,4,6-trimethyl-benzyl)-ethylamine;
(1S)-1-(2,4-Dimethoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(4-trifluoromethyl-benzyl)-ethylamine;
(1S)-1-(5-Fluoro-2-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3,5-Bis-trifluoromethyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Fluoro-2-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(5-Fluoro-2-methoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2-methyl-naphthalen-1-ylmethyl)-ethylamine;
(1S)-1-(2,2-Difluoro-benzo[1,3]dioxol-4-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Fluoro-naphthalen-1-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2,2,3,3-tetrafluoro-2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(4-methyl-naphthalen-1-ylmethyl)-ethylamine;
(1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2,4,6-trifluoro-benzyl)-ethylamine; (1S)-2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2,3,4-trifluoro-benzyl)-ethylamine;
(1S)-1-(4-Bromo-2-fluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Bromo-3-fluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2-Bromo-4,6-difluoro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Bromo-3-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-Bromo-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Methoxy-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(3-Bromo-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(2-Methoxy-naphthalen-1-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1R)-1-(4-Chloro-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1R)-1-Benzo[1,3]dioxol-5-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1R)-1-(3-Fluoro-4-methyl-benzyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-Benzyl-2-[6-chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Bromo-benzyl)-2-[6-chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(4-Chloro-benzyl)-2-[6-chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[6-Chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-cyclohexylmethyl-ethylamine;
(1S)-2-[6-Chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(2,6-dimethyl-benzyl)-ethylamine;
(1S)-1-[6-Chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-2-phenyl-propylamine;
(1S)-1-[6-Chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-2,2-diphenyl-ethylamine;
(1S)-1-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-2-phenyl-propylamine;
(1S)-1-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-2,2-diphenyl-ethylamine;
(1S)-3-Methyl-1-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxymethyl]-butylamine;
(1S)-2-[6-Chloro-5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-(6-Chloro-5-thieno[2,3-c]pyridin-2-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxyl-3-isoquinolin-6-yl-pyridine-2-carbonitrile;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-phenyl-isoquinolin-6-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Ethyl-isoquinolin-6-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-pyridin-4-yl-isoquinolin-6-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(3-Furan-2-yl-isoquinolin-6-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-phenylethynyl-isoquinolin-6-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-prop-1-ynyl-isoquinolin-6-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(3-vinyl-isoquinolin-6-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-6-{5-[2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-isoquinoline-3-carbonitrile;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-6-vinyl-pyridin-3-yloxy)-ethylamine;
(1S)-2-(6-Ethynyl-5-isoquinolin-6-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-(6-Furan-2-yl-5-isoquinolin-6-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-6-phenylethynyl-pyridin-3-yloxy)-ethylamine;
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-isoquinolin-5-ylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(8-methyl-isoquinolin-6-yl)pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(4-Chloro-thieno[2,3-c]pyridin-2-yl)-pyridin-3-yloxy]-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(4-phenyl-thieno[2,3-c]pyridin-2-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(4-phenoxy-thieno[2,3-c]pyridin-2-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(1H-Indol-3-ylmethyl)-2-[5-(4-vinyl-thieno[2,3-c]pyridin-2-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-2-[5-(4-Ethyl-thieno[2,3-c]pyridin-2-yl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-(2-{5-(2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-thieno[2,3-c]pyridin-4-yl)-phenyl-amine;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3,3-difluoro-1,3-dihydro-indol-2-one;
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3H-oxazolo[4,5-b]pyridin-2-one;
N1-(5-Isoquinolin-6-yl-pyridin-3-yl)-ethane-1,2-diamine;
Naphthalene-2-sulfonic acid (2-amino-ethyl)-(5-isoquinolin-6-yl-pyridin-3-yl)-amide;
Naphthalene-1-sulfonic acid (2-amino-ethyl)-(5-isoquinolin-6-yl-pyridin-3-yl)-amide;
5-Dimethylamino-naphthalene-1-sulfonic acid (2-amino-ethyl)-(5-isoquinolin-6-yl-pyridin-3-yl)-amide;
Quinoline-5-sulfonic acid (2-amino-ethyl)-(5-isoquinolin-6-yl-pyridin-3-yl)-amide;
Biphenyl-4-sulfonic acid (2-amino-ethyl)-(5-isoquinolin-6-yl-pyridin-3-yl)-amide;
1-Methyl-1H-imidazole-4-sulfonic acid (2-amino-ethyl)-(5-isoquinolin-6-yl-pyridin-3-yl)-amide;
3-Amino-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propan-1-ol;
2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-3-phenoxy-propylamine;
2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-3-(naphthalen-2-yloxy)-propylamine;
3-(Biphenyl-4-yloxy)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propylamine;
2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-3-(quinolin-7-yloxy)-propylamine;
2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-3-(pyridin-4-yloxy)-propylamine;
2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-3-(naphthalen-1-yloxy)-propylamine;
3-{(2S)-2-Amino-3-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propyl}-1H-indol-5-ol;
(1S)-1-(5-Methoxy-1H-indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(5-Ethoxy-1H-indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(5-Butoxy-1H-indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
(1S)-1-(5-Isopropoxy-1H-indol-3-ylmethyl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
3-(1H-Indol-3-yl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propan-1-ol;
3-(1H-Indol-3-yl)-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-propylamine;
Naphthalene-2-sulfonic acid (2-amino-ethyl)-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-amide;
Biphenyl-4-sulfonic acid (2-amino-ethyl)-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yl]-amide;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-isopropylidene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(1H-imidazol-2-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-pyridin-2-ylmethylene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl }-3-furan-2-ylmethylene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(5-methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(4,5-dimethyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-thiophen-2-ylmethylene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(1-methyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(1H-indol-3-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(1-phenyl-1H-pyrrol-3-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-pyridin-3-ylmethylene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(1H-pyrrol-3-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(tetrahydro-pyran-4-ylidene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-cyclopropylmethylene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-pyrrolidin-2-ylmethylene-1,3-dihydro-indol-2-one;
5-(5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-furan-2-carboxylic acid;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-benzylidene-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1H-indole-2,3-dione 3-oxime;
(1S)-2-(5-Benzo[b]thiophen-2-yl-6-furan-2-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-(5-Benzo[b]thiophen-2-yl-6-vinyl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-(5-Benzo[b]thiophen-2-yl-6-thiophen-2-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-(5-Benzo[b]thiophen-2-yl-6-thiazol-2-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
(1S)-2-(5-Benzo[b]thiophen-2-yl-6-pyridin-2-yl-pyridin-3-yloxy)-1-(1H-indol-3-ylmethyl)-ethylamine;
{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxyl]-3-benzo[b]thiophen-2-yl-pyridin-2-yl}-phenyl-amine;
{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-3-benzo[b]thiophen-2-yl-pyridin-2-yl}-pyridin-3-yl-amine;
6-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3H-benzooxazol-2-one;
1-Benzoimidazol-1-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
2-[5-(3-Methyl-1H-indazol-5-yl)-pyridin-3-yloxyl]-1-morpholin-4-ylmethyl-ethylamine;
5-[5-((2S)-2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-1,3-dihydro-indol-2-one;
5-[5-((2S)-2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one;
5-[5-((2S)-2-Amino-3-phenyl-propoxy)-pyridin-3-yl]-3-furan-2-ylmethylene-1,3-dihydro-indol-2-one;
(1S)-1-Benzoimidazol-1-ylmethyl-2-[5-(3-methyl-1H-indazol-5-yl)-pyridin-3-yloxy]-ethylamine;
3-{3-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-5-isoquinolin-6-yl-pyridin-4-yl}-acrylonitrile;
(1S)-1-(1H-Indol-3-ylmethyl)-2-(5-isoquinolin-6-yl-4-methyl-pyridin-3-yloxy)-ethylamine;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-methyl-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3,3-dimethyl-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-1,3,3-trimethyl-1,3-dihydro-indol-2-one;
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl}-3-ethyl-1,3-dihydro-indol-2-one; and
5-{5-[(2S)-2-Amino-3-(1H-indol-3-yl)-propoxy]-pyridin-3-yl }-3-benzyl-1,3-dihydro-indol-2-one.
21. A pharmaceutical composition comprising a compound of claim 1 or claim 2 , or a therapeutically acceptable salt of both the forgoing, in combination with a pharmaceutically acceptable carrier.Cited by (0)
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