Compositions and methods for the therapy and diagnosis of ovarian cancer

Abstract

Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

1. An isolated antibody, or antigen-binding fragment thereof, that specifically binds to a polypeptide having the amino acid sequence set forth in SEQ ID NO: 312. 
     
     
       2. A diagnostic kit comprising at least one antibody according to  claim 1  and a detection reagent, wherein the detection reagent comprises a reporter group. 
     
     
       3. An isolated antibody of  claim 1 , wherein the antibody specifically binds to amino acid residues of SEQ ID NO: 312 selected from the group consisting of 54-68, 94-108, 104-118, 124-138, 164-178, 274-288, 504-518, 534-548, 544-558, 564-578, 614-628, 624-638, 634-648, 644-658, 744-758, and 774-801. 
     
     
       4. An isolated antibody of  claim 1 , wherein the antibody is a polyclonal antibody. 
     
     
       5. An isolated antibody of  claim 1 , wherein the antibody is a monoclonal antibody. 
     
     
       6. An isolated antibody of  claim 1 , wherein the antibody is a humanized antibody. 
     
     
       7. An isolated antibody of  claim 1  said antibody coupled to a radionuclide. 
     
     
       8. An isolated antibody of  claim 7 , wherein the radionuclide is selected from the group consisting of  90 Y,  123 I,  125 I,  131 I,  186 Re,  188 Re,  211 At, and  212 Bi.