Compositions having enhanced deposition of a topically active compound on a surface

Abstract

Topically active compositions having enhanced effectiveness are disclosed. The compositions contain a topically active compound, an anionic surfactant, a hydric solvent, a hydrotrope, an optional cosurfactant, and water, wherein a percent saturation of the topical active compound of the composition is at least 25%. The compositions exhibit a rapid and effective topical effect, and effectively deposit the topically active compound for an effective residual effect.

1. A topically active composition comprising:
 (a) about 0.001% to about 5%, by weight, of a topically active compound;  
 (b) about 0.1% to about 15%, by weight, of an anionic surfactant;  
 (c) about 0.5% to about 35%, by weight, of a hydrotrope;  
 (d) about 0.5% to about 25%, by weight, of a water-soluble hydric solvent;  
 (e) 0% to about 5%, by weight, of a cosurfactant selected from the group consisting of a nonionic surfactant, an ampholytic surfactant, and mixtures thereof; and  
 (f) water,  
 wherein the topically active compound is present in the composition in an amount of at least 50% of saturation concentration, when measured at room temperature, and the topically active compound is water-insoluble and is selected from the group consisting of an antidandruff agent, a sunscreen, a medicament, a skin conditioner, a hair conditioner, a vitamin, an emollient, an antioxidant, a fragrance, an antiacne agent, a skin protectant, an external analgesic, an ultraviolet light absorber, and mixtures thereof,  
 and wherein upon dilution of one weight part of the composition with 0.33 to 3 parts of water, by weight, a phase separation is observed within one hour.  
 
     
     
       2. The composition of  claim 1  wherein the topically active compound is present in an amount of at least 75% of saturation concentration. 
     
     
       3. The composition of  claim 1  comprising about 0.01% to about 1.5% by weight, of the topically active compound. 
     
     
       4. The composition of  claim 1  wherein the surfactant is present in an amount of about 0.3% to about 8%, by weight of the composition. 
     
     
       5. The composition of  claim 1  wherein the anionic surfactant comprises a C 8 -C 18  alkyl sulfate, a C 8 -C 18  fatty acid salt, a C 8 -C 18  alkyl ether sulfate having one or two moles of ethoxylation, a C 8 -C 18  alkamine oxide, a C 8 -C 18  alkyl sarcosinate, a C 8 -C 18  sulfoacetate, a C 8 -C 18  sulfosuccinate, a C 8 -C 18  alkyl diphenyl oxide disulfonate, a C 8 -C 18  alkyl carbonate, a C 8 -C 18  alpha-olefin sulfonate, a methyl ester sulfonate, and mixtures thereof. 
     
     
       6. The composition of  claim 1  wherein the hydrotrope is present in an amount of about 3% to about 30% by weight. 
     
     
       7. The composition of  claim 1  wherein the hydric solvent present in an amount of about 2% to about 20% by weight. 
     
     
       8. The composition of  claim 1  wherein the hydric solvent comprises an alcohol, a diol, a triol, and mixtures thereof. 
     
     
       9. The composition of  claim 1  wherein the hydrotrope is selected from the group consisting of sodium cumene sulfonate, ammonium cumene sulfonate, ammonium xylene sulfonate, potassium toluene sulfonate, sodium toluene sulfonate, sodium xylene sulfonate, toluene sulfonic acid, xylene sulfonic acid, sodium polynaphthalene sulfonate, sodium polystyrene sulfonate, sodium methyl naphthalene sulfonate, disodium succinate, and mixtures thereof. 
     
     
       10. The composition of  claim 1  having a pH of about 5 to about 8. 
     
     
       11. The composition of  claim 1  comprising about 0.01% to about 0.5%, by weight, of a nonionic surfactant, an ampholytic surfactant, or a mixture thereof. 
     
     
       12. The composition of  claim 1  comprising about 0.001% to about 5.0% of a water-insoluble topically active compound, about 5% to about 15% dipropylene glycol, about 10% to about 20% sodium xylene sulfonate, about 0.5% to about 5% ammonium lauryl sulfate, and 0% to about 5% cocamidopropylbetaine. 
     
     
       13. A method of cleaning a surface and depositing a topically active compound on the surface comprising contacting the surface with a composition of  claim 1 , then rinsing the composition from the surface. 
     
     
       14. The method of  claim 13  wherein the surface is a skin or hair of a mammal. 
     
     
       15. The method of  claim 13  wherein the surface is a hard, inanimate surface.