Fat composition for oral or enternal administration and hexacosanoic acid depressant

Abstract

A fat composition for oral or enteral administration which contains eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C 20 or higher monoenoic acid and/or a derivative thereof and functions to diminish hexacosanoic acid; and a hexacosanoic acid depressant which comprises as active ingredients eicosapentaenoic acid and/or a derivative thereof, docosahexaenoic acid and/or a derivative thereof, and a C 20 or higher monoenoic acid and/or a derivative thereof. They can be prepared by extraction from a fish oil or the like, purification, blending, etc. Based on the function of diminishing hexacosanoic acid, the composition and the depressant produce an aging-inhibitory effect on cell membranes, which is effective in the prevention and treatment of lifestyle-related diseases.

1. A fat composition for oral administration which comprises 20 to 200 mg of eicosapentaenoic acid and/or a derivative thereof per one gram of the fat composition, 20 to 200 mg of docosahexaenoic acid and/or a derivative thereof per one gram of the fat composition, 100 to 400 mg of a C 20  or higher monoenoic acid and/or a derivative thereof per one gram of the fat composition, and reduces hexacosanoic acid at a rate of at least 20% in erythrocyte membrane. 
     
     
       2. A fat composition for oral administration according to  claim 1 , which further comprises Vitamins A and D and wherein the content of Vitamins A and D per one gram of the fat composition is 75 μg or less and 2.5 μg or less, respectively. 
     
     
       3. A hexacosanoic acid depressant composition which comprises as active ingredients 20 to 200 mg of eicosapentaenoic acid and/or a derivative thereof per one gram of the composition 20 to 200 mg of docosahexaenoic acid and/or a derivative thereof per one gram of the composition, 100 mg to 400 mg of a C 20  or higher monoenoic acid and/or a derivative thereof per one gram of the composition and optionally Vitamins A and D, wherein the hexacosanoic acid depressant composition reduces hexacosanoic acid at a rate of at least 20% in erythrocyte membrane. 
     
     
       4. A hexacosanoic acid depressant composition according to  claim 3 , wherein the content of Vitamins A and D per one gram of the hexacosanoic acid depressant is 75 μg or less and 2.5 μg or less, respectively. 
     
     
       5. A method of reducing hexacosanoic acid in a subject, measured as a ratio of hexacosanoic acid to total fatty acid, said method comprising orally administering
 eicosapentaenoic acid and/or a derivative thereof in an amount of 1 to 60 mg/body weight (kg)/day  
 docosahexaenoic acid and/or a derivative thereof in an amount of 1 to 75 mg/body weight (kg)/day, and  
 a C 20  or higher monoenoic acid and/or a derivative thereof in an amount of 5 to 150 mg/body weight (kg)/day, provided that hexacoanoic acid is reduced at least 20% in erythrocyte membrane.