Artificial dura mater having cell adhesiveness and a process for producing the same

Abstract

The present invention provides a material having adhesiveness to bone and/or fascia, which is composed of a polymeric material comprising carbon as a constituent element, and at least a part of a surface of which is modified by ion bombardment. The material of the present invention is applicable as a prosthesis in surgery of spinal diseases and as a prosthesis in surgery on thoracic organs and abdominal organs or musculoskeleton in addition to the application thereof to the artificial dura mater.

1. A material for an artificial dura mater which is composed of material having adhesiveness to at least one of bone or fascia, said material being composed of a polymeric material comprising carbon as a constituent element, and at least a part of a surface of the polymeric material is modified by ion bombardment. 
     
     
       2. A method for adhering a material having adhesiveness to at least one of bone or fascia comprising applying a polymeric material to at least one of bone or fascia, the polymeric material comprising carbon as a constituent element, and at least a part of a surface of the polymeric material is modified by ion bombardment so that the polymeric material has adhesiveness to at least one or bone or fascia. 
     
     
       3. The method according to  claim 2  wherein the polymeric material comprising carbon as a constituent element is expanded polytetrafluoroethylene (ePTFE), polylactic acid, or glycolic-lactic acid polyester. 
     
     
       4. The method according to  claim 2  wherein modification by ion bombardment is performed by ion implantation in a dose φ range of 1×10 13 ≦φ<1×10 16  ions/cm 2 . 
     
     
       5. A method for filling a dura mater defect comprising applying a polymeric material to the dura mater defect, the polymeric material comprising carbon as a constituent element, and at least a part of a surface of the polymeric material is modified by ion bombardment. 
     
     
       6. The method according to  claim 5  wherein the polymeric material comprising carbon as a constituent element is expanded polytetrafluoroethylene (ePTFE), polylactic acid, or glycolic-lactic acid polyester. 
     
     
       7. The method according to  claim 5  wherein modification by ion bombardment is performed by ion implantation in a dose φ range of 1×10 13 ≦φ<1×10 16  ions/cm 2 .