Potassium taurate bicarbonate and ascorbate

Abstract

Compositions comprising potassium taurate bicarbonate complexes and/or potassium taurate ascorbate complexes are useful as pharmaceutical compositions and as dietary ingredients in nutritional supplements, medical foods, and other foods. In preferred embodiments, potassium taurate bicarbonate and/or potassium taurate ascorbate complexes are the active ingredient in antihypertensive drug products that are intended to lower or prevent elevated blood pressure, or as dietary ingredients in dietary supplements, medical foods or other foods that are intended to supply a source of potassium, taurine, ascorbate, and/or bicarbonate, or that are intended to help maintain normal blood pressure levels and/or normal muscle mass. In preferred embodiments, potassium taurate bicarbonate complexes are prepared by intermixing potassium bicarbonate and taurine in aqueous solutions, and potassium taurate ascorbate complexes are prepared by intermixing potassium ascorbate and taurine in aqueous solutions.

1. A composition comprising a complex selected from the group consisting of potassium taurate bicarbonate complex and potassium taurate ascorbate complex, and optionally sodium, the composition containing more potassium than sodium on a weight basis. 
     
     
       2. The composition of  claim 1  in which the complex is potassium taurate bicarbonate complex. 
     
     
       3. The composition of  claim 1  in which the complex is potassium taurate ascorbate complex. 
     
     
       4. The composition of  claim 1  in which the complex comprises a mixture of potassium taurate bicarbonate complex and potassium taurate ascorbate complex. 
     
     
       5. The composition of  claim 1  in solid form. 
     
     
       6. The composition of  claim 1  in liquid form. 
     
     
       7. The composition of  claim 1  having a potassium:taurine molar ratio in the range of about 1:10 to about 10:1. 
     
     
       8. The composition of  claim 1  having a potassium:taurine molar ratio in the range of about 1:2 to about 2:1. 
     
     
       9. The composition of  claim 1  further comprising an edible carrier. 
     
     
       10. The composition of  claim 9  in which the complex comprises at least about 25%, by weight, of the composition. 
     
     
       11. The composition of  claim 9  in which the complex comprises at least about 50%, by weight, of the composition. 
     
     
       12. The composition of  claim 1  in the form of a pharmaceutical composition. 
     
     
       13. The composition of  claim 1  in the form of a dietary ingredient. 
     
     
       14. The composition of  claim 13  in the form of a medical food. 
     
     
       15. The composition of  claim 13  in the form of a dietary supplement. 
     
     
       16. The composition of  claim 13 , further comprising food. 
     
     
       17. A method for supplementing a diet, comprising administering the composition of  claim 1  to a mammal. 
     
     
       18. The method of  claim 17 , comprising administering the composition of  claim 1  to the mammal in an amount effective to provide the mammal with from about 100 milligrams to about 5,000 milligrams of potassium per day. 
     
     
       19. The method of  claim 17 , comprising administering the composition of  claim 1  to the mammal in an amount effective to provide the mammal with from about 100 milligrams to about 10,000 milligrams of taurine per day. 
     
     
       20. The method of  claim 17  in which the complex is potassium taurate bicarbonate complex, comprising administering the composition of  claim 1  to the mammal in an amount effective to provide the mammal with from about 25 milligrams to about 7,500 milligrams of bicarbonate per day. 
     
     
       21. The method of  claim 17  in which the complex is potassium taurate ascorbate complex, comprising administering the composition of  claim 1  to the mammal in an amount effective to provide the mammal with from about 25 milligrams to about 7,500 milligrams of ascorbate per day. 
     
     
       22. The method of  claim 17  in which the mammal is a cat. 
     
     
       23. The method of  claim 17  in which the mammal is a human. 
     
     
       24. The method of  claim 23  in which the human has a daily sodium intake, comprising administering the composition of  claim 1  to the human in an amount effective to provide the human with a daily potassium intake that is greater than the daily sodium intake. 
     
     
       25. The method of  claim 24  comprising administering the composition of  claim 1  to the human in an amount effective to provide the human with a daily potassium intake that is at least about double the daily sodium intake. 
     
     
       26. A method for treating hypokalemia, comprising
 identifying a mammal suffering from hypokalemia; and  
 administering the composition of  claim 1  to the mammal in an amount effective to treat the hypokalemia.  
 
     
     
       27. The method of  claim 26  in which the mammal is a human. 
     
     
       28. The method of  claim 26  in which the amount effective to treat the hypokalemia is an amount effective to provide the mammal with from about 100 milligrams to about 5,000 milligrams of potassium per day. 
     
     
       29. A method for treating a hypertensive condition, comprising
 identifying a mammal suffering from a hypertensive condition; and  
 administering the composition of  claim 1  to the mammal in an amount effective to treat the hypertensive condition.  
 
     
     
       30. The method of  claim 29  in which the mammal is a human. 
     
     
       31. The method of  claim 30  in which the amount effective to treat the hypertensive condition is an amount effective to provide the human with from about 100 milligrams to about 5,000 milligrams of potassium per day. 
     
     
       32. A method for maintaining normal healthy blood pressure, normal healthy muscle mass, or both, comprising administering the composition of  claim 1  to a mammal in an amount effective to maintain normal healthy blood pressure, normal healthy muscle mass, or both. 
     
     
       33. A method for making the composition of  claim 1  in which the complex is potassium taurate bicarbonate complex, comprising intermixing potassium bicarbonate, taurine and water. 
     
     
       34. The method of  claim 33  in which the intermixing is conducted at a molar ratio of the potassium bicarbonate to the taurine in the range of about 1:10 to about 10:1. 
     
     
       35. The method of  claim 33  in which the intermixing is conducted at a molar ratio of the potassium bicarbonate to the taurine in the range of about 1:2 to about 2:1. 
     
     
       36. The method of  claim 33 , further comprising evaporating the water to produce a solid potassium taurate bicarbonate complex. 
     
     
       37. The method of  claim 33  in which the intermixing produces an aqueous solution having a pH in the range of about 7.0 to about 7.8. 
     
     
       38. A method for making the composition of  claim 1  in which the complex is potassium taurate ascorbate complex, comprising intermixing potassium ascorbate, taurine and water. 
     
     
       39. The method of  claim 38  in which the intermixing is conducted at a molar ratio of the potassium ascorbate to the taurine in the range of about 1:10 to about 10:1. 
     
     
       40. The method of  claim 38  in which the intermixing is conducted at a molar ratio of the potassium ascorbate to the taurine in the range of about 1:2 to about 2:1. 
     
     
       41. The method of  claim 38 , further comprising evaporating the water to produce a solid potassium taurate ascorbate complex. 
     
     
       42. A packaged liquid composition comprising about 300 to about 1,500 grams of water and about 100 mg to about 15 grams of a complex selected from the group consisting of potassium taurate bicarbonate complex and potassium taurate ascorbate complex; and optionally sodium. 
     
     
       43. The packaged liquid composition of  claim 42  in which the complex is potassium taurate bicarbonate complex. 
     
     
       44. The packaged liquid composition of  claim 42  in which the complex is potassium taurate ascorbate complex. 
     
     
       45. The packaged liquid composition of  claim 42  containing more potassium than sodium on a weight basis. 
     
     
       46. The packaged liquid composition of  claim 42  comprising about 250 mg to about 2500 mg of potassium. 
     
     
       47. The packaged liquid composition of  claim 42  comprising about 500 mg to about 2,000 mg of potassium. 
     
     
       48. The packaged liquid composition of  claim 46  comprising about 100 mg to about 10,000 mg of taurine. 
     
     
       49. The packaged liquid composition of  claim 46  comprising about 25 mg to about 7,500 mg of bicarbonate. 
     
     
       50. A packaged liquid composition consisting essentially of water and a complex selected from the group consisting of potassium taurate bicarbonate complex and potassium taurate ascorbate complex.