US6891025B2ExpiredUtilityA1

Modified cytokine receptor protein

Assignee: PHARMACIA ABPriority: Feb 18, 1997Filed: Feb 17, 1998Granted: May 10, 2005

Est. expiryFeb 18, 2017(expired)· nominal 20-yr term from priority

Inventors:Michael Sundstrom Gunnar Norstedt

C07K 14/715A61K 38/00C07K 1/306C07K 14/71C07K 14/72

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References

Claims

Abstract

A modified extracellular domain of a cytokine receptor is capable of being crystallized without being complexed to a ligand molecule. The receptor preferably is a homo- or heterodemeric receptor having at least one molecule segment which contributes to a disorder structure deleted. A preferred receptor is human growth hormone receptor (hGHR).

Claims

exact text as granted — not AI-modified

1. A human growth hormone receptor (hGHR) consisting of residues 32-237 (SEQ ID NO: 2), 32-234 (SEQ ID NO: 3), or 34-23 3 (SEQ ID NO: 4), of the native hGHR molecule. 
     
     
       2. A human growth hormone receptor (hGHR) according to  claim 1  consisting of residues 32-237 (SEQ ID NO: 2), of the native hGHR molecule.

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