Methods and compositions relating to CD39-like polypeptides and nucleic acids

Abstract

The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides and polynucleotides of the invention comprise amino acid and nucleic acid sequences of novel CD39-like gene and gene products.

1. An isolated CD39L3 polypeptide comprising the amino acid sequence of SEQ ID NO: 4. 
     
     
       2. An isolated polypeptide having phosphohydrolase activity consisting of the amino acid sequence of SEQ ID NO: 4. 
     
     
       3. A composition comprising:
 (a) a polypeptide selected from the group consisting of: 
 (i) a polypeptide comprising the amino acid sequence of SEQ ID NO: 4, and  
 (ii) a polypeptide having phosphohydrolase activity consisting of the amino acid sequence of SEQ ID NO: 4; and  
 
 (b) a carrier.  
 
     
     
       4. The polypeptide according to any one of claims  1 - 2  that comprises amino acid residues 55-76, 132-150, 177-199 or 213-234 of SEQ ID NO: 4.